Array

Publications

For a Comprehensive List, please see Google Scholar

Selected Publications

Bruin JE, Saber N, Braun N, Fox JK, Mojibian M, Asadi A, Drohan C, O’Dwyer S, Balzer D, Rezania A, Kieffer TJ (2015). Treating diet-induced diabetes and obesity with macroencapsulated human embryonic stem cell-derived progenitor cells and antidiabetic drugs. Stem Cell Reports. 4(4):605-20.

Denroche HC, Kwon MM, Quong WL, Neumann UH, Kulpa JE, Karunakaran S, Clee SM, Brownsey RW, Covey SD, Kieffer TJ (2015). Leptin induces fasting hypoglycaemia in diabetic mice through the depletion of glycerol. Diabetologia. 58(5):1100-8.

Rezania A, Bruin JE, Arora P, Rubin A, Batushansky I, Asadi A, O’Dwyer S, Mojibian M, Albrecht T, Yang YHC, Johnson JD, Kieffer TJ. (2014). Reversal of diabetes with insulin producing cells derived in vitro from human pluripotent stem cells. Nature Biotechnology. 32(11): 1121-1133.

Mojibian M, Lam AW, Fujita Y, Asadi A, Grassl GA, Dickie P, Tan R, Cheung AT, Kieffer TJ (2014). Insulin-producing intestinal K cells protect nonobese diabetic mice from autoimmune diabetes. Gastroenterology. 147(1): 162-171.

D’souza AM, Asadi A, Johnson JD, Covey SD, Kieffer TJ (2014). Leptin deficiency in rats results in hyperinsulinemia and impaired glucose homeostasis. Endocrinology. 155(4): 1268-79.

Neumann UH, Chen S, Tam YY, Baker RK, Covey SD, Cullis PR, Kieffer TJ (2014). IGFBP2 is neither sufficient nor necessary for the physiological actions of leptin on glucose homeostasis in male ob/ob mice. Endocrinology. 155(3): 716-25.

Rezania A , Bruin JE, Xu J , Narayan K , Fox JK, O’Neil JJ, Kieffer TJ. (2013). Enrichment of human embryonic stem cell-derived NKX6.1-expressing pancreatic progenitor cells accelerates the maturation of insulin-secreting cells in vivo. Stem Cells. 31(11): 2432-42.

Mojibian M, Harder B, Hurlburt A, Bruin JE, Asadi A, Kieffer TJ (2013). Implanted islets in the anterior chamber of the eye are prone to autoimmune attack in a mouse model of diabetes. Diabetologia. 56(10): 2213-21.

Bruin JE, Rezania A , Xu J , Narayan K , Fox JK, O’Neil JJ , Kieffer TJ. (2013). Maturation and function of human embryonic stem cell-derived pancreatic progenitors in macroencapsulation devices following transplant into mice. Diabetologia. 56(9): 1987-98.

Denroche HC, Quong WL, Bruin JE, Tuduri E, Asadi A, Glavas MM, Fox JK, Kieffer TJ. (2013). Leptin administration enhances islet transplant performance in diabetic mice. Diabetes. 62(8): 2738-46.

Huynh FK, Neumann UH, Wang Y, Rodrigues B, Kieffer TJ, Covey SD. (2013). A role for hepatic leptin signaling in lipid metabolism via altered very low density lipoprotein composition and liver lipase activity in mice. Hepatology. 57(2): 543-54.

Erener S, Mojibian M, Fox JK, Denroche HC, Kieffer TJ. (2013). Circulating miR-375 as a biomarker of β-cell death and diabetes in mice. Endocrinology. 154(2): 603-8.

Levi J, Huynh FK, Denroche HC, Neumann UH, Glavas MM, Covey SD, Kieffer TJ. (2012). Hepatic leptin signalling and subdiaphragmatic vagal efferents are not required for leptin-induced increases of plasma IGF binding protein-2 (IGFBP-2) in ob/ob mice. Diabetologia. 55(3): 752-62.

Riedel MJ, Asadi A, Wang R, Ao Z, Warnock GL, Kieffer TJ (2012). Immunohistochemical characterisation of cells co-producing insulin and glucagon in the developing human pancreas. Diabetologia. 55(2): 372-81.

Levi J, Gray SL, Speck M, Huynh FK, Babich SL, Gibson WT, Kieffer TJ (2011). Acute disruption of leptin signaling in vivo leads to increased insulin levels and insulin resistance. Endocrinology. 152(9): 3385-95.

Denroche HC, Levi J, Wideman RD, Sequeira RM, Huynh FK, Covey SD, Kieffer TJ (2011). Leptin therapy reverses hyperglycemia in mice with streptozotocin-induced diabetes, independent of hepatic leptin signaling. Diabetes. 60(5): 1414-23.

Rezania A, Riedel MJ, Wideman RD, Karanu F, Ao Z, Warnock GL, Kieffer TJ (2011). Production of functional glucagon-secreting α-cells from human embryonic stem cells. Diabetes. 60(1): 239-47.

Huynh FK, Levi J, Denroche HC, Gray SL, Voshol PJ, Neumann UH, Speck M, Chua SC, Covey SD, Kieffer TJ (2010). Disruption of hepatic leptin signaling protects mice from age- and diet-related glucose intolerance. Diabetes. 59(12): 3032-40.

Gray SL, Donald C, Jetha A, Covey SD, Kieffer TJ (2010). Hyperinsulinemia precedes insulin resistance in mice lacking pancreatic beta-cell leptin signaling. Endocrinology. 151(9): 4178-86.

Fujita Y, Wideman RD, Asadi A, Yang GK, Baker R, Webber T, Zhang T, Wang R, Ao Z, Warnock GL, Kwok YN, Kieffer TJ (2010). Glucose-dependent insulinotropic polypeptide is expressed in pancreatic islet alpha-cells and promotes insulin secretion. Gastroenterology. 138(5): 1966-75.

Fujita Y, Wideman RD, Speck M, Asadi A, King DS, Webber TD, Haneda M, Kieffer TJ (2009). Incretin release from gut is acutely enhanced by sugar but not by sweeteners in vivo. American Journal of Physiology – Endocrinology and Metabolism. 296(3): E473-9.

Cleavage of protein kinase D after acute hypoinsulinemia prevents excessive lipoprotein lipase-mediated cardiac triglyceride accumulation. Kim MS, Wang F, Puthanveetil P, Kewalramani G, Innis S, Marzban L, Steinberg SF, Webber TD, Kieffer TJ, Abrahani A, Rodrigues B. Diabetes. 2009 Nov;58(11):2464-75.

Alotaketals A and B, sesterterpenoids from the marine sponge Hamigera species that activate the cAMP cell signaling pathway. Forestieri R, Merchant CE, de Voogd NJ, Matainaho T, Kieffer TJ, Andersen RJ. Org Lett. 2009 Nov 19;11(22):5166-9.

DsAAV8-mediated expression of glucagon-like peptide-1 in pancreatic beta-cells ameliorates streptozotocin-induced diabetes. Riedel MJ, Gaddy DF, Asadi A, Robbins PD, Kieffer TJ. Gene Ther. 2009 Oct 29. [Epub ahead of print]

Mining incretin hormone pathways for novel therapies. Wideman RD, Kieffer TJ. Trends Endocrinol Metab. 2009 Aug;20(6):280-6. Review.

Treatment of diabetes by transplantation of drug-inducible insulin-producing gut cells. Unniappan S, Wideman RD, Donald C, Gunn V, Wall JL, Zhang QX, Webber TD, Cheung AT, Kieffer TJ. J Mol Med. 2009 Jul;87(7):703-12. Epub 2009 Apr 23.

Regulation of somatostatin release by adenosine in the mouse stomach. Yang GK, Chen JF, Kieffer TJ, Kwok YN. J Pharmacol Exp Ther. 2009 May;329(2):729-37. Epub 2009 Feb 10. Erratum in: J Pharmacol Exp Ther. 2009 Jun;329(3):1187.

Engineered glucagon-like peptide-1-producing hepatocytes lower plasma glucose levels in mice. Riedel MJ, Lee CW, Kieffer TJ. Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E936-44. Epub 2009 Feb 3.

Ontogeny of ghrelin, obestatin, preproghrelin, and prohormone convertases in rat pancreas and stomach. Walia P, Asadi A, Kieffer TJ, Johnson JD, Chanoine JP. Pediatr Res. 2009 Jan;65(1):39-44.

Exercise restores endothelial function independently of weight loss or hyperglycaemic status in db/db mice. Moien-Afshari F, Ghosh S, Elmi S, Rahman MM, Sallam N, Khazaei M, Kieffer TJ, Brownsey RW, Laher I. Diabetologia. 2008 Jul;51(7):1327-37. Epub 2008 Apr 25. Erratum in: Diabetologia. 2009 Jan;52(1):181. Elmi, S [added]; Rahman, M M [added]; Sallam, N [added].

Oosman SN, Lam AW, Harb G, Unniappan S, Lam NT, Webber T, Bruch D, Zhang QX, Korbutt GS, Kieffer TJ (2008). Treatment of obesity and diabetes in mice by transplant of gut cells engineered to produce leptin. Molecular Therapy. 16(6): 1138-45.

Incretin release from gut is acutely enhanced by sugar but not by sweeteners in vivo. Fujita Y, Wideman RD, Speck M, Asadi A, King DS, Webber TD, Haneda M, Kieffer TJ. Am J Physiol Endocrinol Metab. 2009 Mar;296(3):E473-9. Epub 2008 Dec 23.

Transplantation of PC1/3-Expressing alpha-cells improves glucose handling and cold tolerance in leptin-resistant mice. Wideman RD, Gray SL, Covey SD, Webb GC, Kieffer TJ. Mol Ther. 2009 Jan;17(1):191-8. Epub 2008 Oct 21.

Pax6 and Pdx1 are required for production of glucose-dependent insulinotropic polypeptide in proglucagon-expressing L cells. Fujita Y, Chui JW, King DS, Zhang T, Seufert J, Pownall S, Cheung AT, Kieffer TJ. Am J Physiol Endocrinol Metab. 2008 Sep;295(3):E648-57. Epub 2008 Jul 1.

Metabolic effects of chronic obestatin infusion in rats. Unniappan S, Speck M, Kieffer TJ. Peptides. 2008 Aug;29(8):1354-61. Epub 2008 Apr 16.

Leptin extends the anorectic effects of chronic PYY(3-36) administration in ad libitum-fed rats. Unniappan S, Kieffer TJ. Am J Physiol Regul Integr Comp Physiol. 2008 Jul;295(1):R51-8. Epub 2008 Apr 16.

Treatment of obesity and diabetes in mice by transplant of gut cells engineered to produce leptin. Oosman SN, Lam AW, Harb G, Unniappan S, Lam NT, Webber T, Bruch D, Zhang QX, Korbutt GS, Kieffer TJ. Mol Ther. 2008 Jun;16(6):1138-45. Epub 2008 Apr 15.

Effect of exercise on augmented aortic vasoconstriction in the db/db mouse model of type-II diabetes. Khazaei M, Moien-Afshari F, Kieffer TJ, Laher I. Physiol Res. 2008;57(6):847-56. Epub 2007 Nov 30

Wideman RD, Covey SD, Webb GC, Drucker DJ, Kieffer TJ (2007). A switch from prohormone convertase (PC)-2 to PC1/3 expression in transplanted alpha-cells is accompanied by differential processing of proglucagon and improved glucose homeostasis in mice. Diabetes. 56(11): 2744-52.

Wideman RD, Covey SD, Webb GC, Drucker DJ, Kieffer TJ. A switch from prohormone convertase (PC)-2 to PC1/3 expression in transplanted alpha-cells is accompanied by differential processing of proglucagon and improved glucose homeostasis in mice. Diabetes. 56:2744-52. (2007)

Covey SD, Wideman RD, McDonald C, Unniappan S, Huynh F, Asadi A, Speck M, Webber T, Chua SC, Kieffer TJ (2006). The pancreatic beta cell is a key site for mediating the effects of leptin on glucose homeostasis. Cell Metabolism. 4(4): 291-302.

Wideman RD, Yu IL, Webber TD, Verchere CB, Johnson JD, Cheung AT, Kieffer TJ (2006). Improving function and survival of pancreatic islets by endogenous production of glucagon-like peptide 1 (GLP-1). Proceedings of the National Academy of Sciences of the United States of America. 103(36):13468-73.

Covey SD, Wideman RD, McDonald C, Unniappan S, Huynh F, Asadi A, Speck M, Webber T, Chua SC, Kieffer TJ. The pancreatic beta cell is a key site for mediating the effects of leptin on glucose homeostasis. Cell Metab. 4:291-302. (2006)

Wideman RD, Yu IL, Webber TD, Verchere CB, Johnson JD, Cheung AT, Kieffer TJ. Improving function and survival of pancreatic islets by endogenous production of glucagon-like peptide 1 (GLP-1). Proc Natl Acad Sci U S A. 103:13468-73. (2006)

Unniappan S, McIntosh CH, Demuth HU, Heiser U, Wolf R, Kieffer TJ. Effects of dipeptidyl peptidase IV on the satiety actions of peptide YY. Diabetologia. 49:1915-23. (2006)

Lam NT, Covey SD, Lewis JT, Oosman S, Webber T, Hsu EC, Cheung AT, Kieffer TJ. Leptin resistance following over-expression of protein tyrosine phosphatase 1B in liver. J Mol Endocrinol. 36:163-74. (2006)

Lam N.T., Lewis J.T., Cheung A.T., Luk L.T., Wang J., Kolls J.K., and Kieffer T.J. Leptin increases hepatic insulin sensitivity and protein tyrosine phosphatase-1B expression. Mol. Endocrinol . 18:1333-1345, (2004).

Fujita Y., Cheung A.T., and Kieffer T.J. Harnessing the gut to treat diabetes. Pediatr. Diabetes 5 Suppl. 2:57-69 (2004).

Cheung A.T., and Kieffer T.J. Gene therapy for metabolic disease. In: Diabetes Mellitus: A Fundamental and Clinical Text, 3 rd Edition, D. LeRoith, S.I. Taylor and M. Olefsky (eds.), Lippincott Williams & Wilkins, Philadelphia PA pp 747-762 (2004).

Cheung A.T., Dayanandan B., Lewis J.T., Korbutt G.S., Rajotte R.V., Boylan M.O., Wolfe M.M., and Kieffer T.J. Glucose-dependent insulin release from genetically engineered K cells. Science 290:1959-1962 (2000).

Kieffer T.J., and Habener J.F. The adipoinsular axis: effects of leptin on pancreatic beta-cells. Am. J. Physiol. 278:E1-E14 (2000).

Stoffers D.A., Kieffer T.J., Hussain M.A., Drucker D.J., Bonner-Weir S., Habener J.F., and Egan J.M. Insulinotropic glucagon-like peptide-1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas. Diabetes 49:741-748 (2000).

Lewis J.T., Dayanandan B., Habener J.F., and Kieffer T.J. Glucose-dependent insulinotropic polypeptide confers early phase insulin release to oral glucose in rats: demonstration by a receptor antagonist. Endocrinology 141:3710-3716 (2000).

Seufert J.R., Kieffer T.J., and Habener J.F. Leptin inhibits insulin gene transcription and reverses hyperinsulinemia in leptin-deficient ob/ob mice. Proc. Natl. Acad. Sci. USA 96:674-679 (1999).

Kieffer T.J., and Habener J.F. The glucagon-like peptides. Endocr. Rev. 20:1-38 (1999).

Kieffer T.J., Heller R.S., Leech C.A., Holz G.G., and Habener J.F. Leptin suppression of insulin secretion by the activation of ATP-sensitive K + channels in pancreatic b -cells. Diabetes 46:1087-1093 (1997).

Kieffer T.J., McIntosh C.H.S., and Pederson R.A. Degradation of glucose-dependent insulinotropic polypeptide (GIP) and truncated glucagon-like peptide-1 (tGLP-1) in vitro and in vivo by dipeptidyl peptidase IV. Endocrinology 136:3585-3596 (1995).

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