Array

Publications

Jia, X., Brown, J.C., Pederson, R.A. and McIntosh, C.H.S. The effects of glucose dependent insulinotropic polypeptide and glucagon-like peptide 1(7-36) on insulin secretion. American Journal of Physiology 268: E645-E651, 1995.

Wheeler, M.B., Gelling, R.W., McIntosh, C.H.S., Georgiu, J., Brown, J.C., and Pederson, R.A. Functional expression of the rat pancreatic islet glucose-dependent insulinotropic polypeptide (GIP) receptor. Endocrinology 136: 4629-4639, 1995.

McIntosh, C.H.S., Wheeler, M.B., Gelling, R.W., Brown, J.C. and Pederson, R.A. GIP receptors and signal-transduction mechanisms. Acta Physiologica Scandinavica 157: 361-365, 1996.

Gelling, R.W., Wheeler, M.B., Xue, J., Gyomorey, S., Nian, C., Pederson, R.A., McIntosh, C.H.S. Localization of the domains involved in ligand binding and activation of the glucose-dependent insulinotropic polypeptide receptor. Endocrinology 138: 2640-2643, 1997.

Wheeler, M.B., Gelling, R.W., Hinke, S., Tu, B., Pederson, R.A., Lynn F., Ehses, J., and McIntosh, C.H.S. Characterization of the carboxyl-terminal domain of the glucose-dependent insulinotropic polypeptide (GIP) receptor. Journal of Biological Chemistry 274: 24593-24601, 1999.

Ehses, J.A., Lee, S.T., Pederson, R.A. and McIntosh, C.H.S. A new pathway for glucose-dependent insulinotropic polypeptide (GIP) receptor signalling. Journal of Biological Chemistry (In Press).

Jia, X., Elliott R., Kwok, Y.N., Pederson, R.A. and McIntosh, C.H.S. Altered glucose dependence of glucagon-like peptide 1(7-36)-induced insulin secretion from the Zucker (fa/fa) rat pancreas. Diabetes 44: 495-500, 1995.

Lynn, F.C., Pamir, N., Ng, E.H.C., McIntosh, C.H.S., and Pederson, R.A. Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats. Diabetes 50:1004-1011, 2001.

Kieffer, T.J., McIntosh, C.H.S., Pederson, R.A. Degradation of glucose-dependent insulinotropic polypeptide (GIP) and truncated glucagon-like peptide 1 (tGLP-1) in vitro and in vivo by dipeptidyl peptidase IV. Endocrinology 136: 3585-3596, 1995.

Pauly, R.P. Rosche, F., Wermann, M., McIntosh, C.H.S., Pederson, R.A. and Demuth H-U. Investigation of GIP1-42 and GLP-1 7-36 degradation in vitro by dipeptidyl peptidase IV (DP IV) using Matrix-Assisted Laser Desorption/Ionization – Time of Flight Mass Spectometry (MALDI-TOF MS): a novel kinetic approach. Journal of Biological Chemistry 271: 23222-23229, 1996.

Hinke, S. A., Pospisilik,J.A., Demuth, H.-U., Mannhart, S., Kühn-Wache, K., Hoffmann, T., Nishimura, E., Pederson, R. A. and McIntosh, C.H.S. Dipeptidyl peptidase IV (DPIV/CD26) degradation of glucagon. Characterization of glucagon degradation products and DPIV-resistant analogs. Journal of Biological Chemistry 275: 3827-3834, 2000.

Morrow, G.W., Kieffer, T., McIntosh, C.H.S., MacGillivray, R.T.A., Brown, J.C. and Pederson, R.A. The insulinotropic region of gastric inhibitory polypeptide; fragment analysis suggests the bioactive site lies between residues 19 and 30. Canadian Journal of Physiology 74: 65-72, 1996.

Gelling, R.W., Coy, D., Pederson, R.A., Wheeler, M.B., O’Dorisio T., Hinke, S., McIntosh, C.H.S. GIP6-30 amide contains the high affinity binding region of GIP and is a potent inhibitor of GIP1-42 action in vitro. Regulatory Peptides 69: 151-154, 1997.

Hinke, A.A., Manhart, S., Pamir, N., Demuth, H.-U., Gelling, R.W., Pederson, R.A. and McIntosh.C.H.S. Identification of a bioactive domain in the amino-terminus of glucose-dependent insulinotropic polypeptide (GIP) Biochimica Biophysica Acta 364: 1-13, 2001.

Pederson R.A., White H. Schlenzig D., Schmidt J., McIntosh, C.H.S., Demuth H.-U. Improved glucose tolerance in Zucker fatty rats by oral administration of the dipeptidyl peptidase IV (DP IV) inhibitor, Ile-thiazolidide. Diabetes 47: 1253-1258, 1998.

Kim SJ, Nian C, Widenmaier S, McIntosh CH. Glucose-dependent Insulinotropic Polypeptide (GIP) mediated up-regulation of {beta}-cell anti-apoptotic Bcl-2 gene expression is coordinated by cAMP-response element binding protein (CREB) and cAMP-responsive CREB coactivator 2 (TORC2). Mol Cell Biol. 2007

McIntosh CH. Dipeptidyl peptidase IV inhibitors and diabetes therapy.
Front Biosci. 2008 13:1753-73. Review.

Kim SJ, Nian C, McIntosh CH. Resistin is a key mediator of glucose-dependent insulinotropic polypeptide (GIP) stimulation of lipoprotein lipase (LPL) activity in adipocytes. J Biol Chem. 2007 282:34139-47.

Piteau S, Olver A, Kim SJ, Winter K, Pospisilik JA, Lynn F, Manhart S, Demuth HU, Speck M, Pederson RA, McIntosh CH. Reversal of islet GIP receptor down-regulation and resistance to GIP by reducing hyperglycemia in the Zucker rat.
Biochem Biophys Res Commun. 2007 362:1007-12.

Kim SJ, Nian C, McIntosh CH. Activation of lipoprotein lipase by glucose-dependent insulinotropic polypeptide in adipocytes. A role for a protein kinase B, LKB1, and AMP-activated protein kinase cascade. J Biol Chem. 2007 282:8557-67.

Kim SJ, Doudet DJ, Studenov AR, Nian C, Ruth TJ, Gambhir SS, McIntosh CH. Quantitative micro positron emission tomography (PET) imaging for the in vivo determination of pancreatic islet graft survival. Nat Med. 2006 12:1423-8.

Kim SJ, Choi WS, Han JS, Warnock G, Fedida D, McIntosh CH. A novel mechanism for the suppression of a voltage-gated potassium channel by glucose-dependent insulinotropic polypeptide: protein kinase A-dependent endocytosis. J Biol Chem. 2005 280:28692-700.

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