The Kieffer lab has the capacity to address questions from molecular to cellular to whole organism, using model cell lines, differentiated stem cells, zebrafish and genetically engineered rodents. We utilize tissue-specific knockdown or reintroduction of genes, cell transplant and surgical manipulations to address the role of hormone actions in a site-specific manner. We assess the effects of environment on metabolic function with dietary manipulations, from neonates to adults. We have advanced equipment for high-throughput analyses of cellular function and pathways, for whole animal imaging, and for metabolic phenotyping. Through strong networks of collaborators including basic scientists and clinicians, we have assembled and led multidisciplinary teams and effectively engaged researchers across Canada and around the world to support our research enterprise. We actively collaborate with industry, including large pharmaceutical companies, as we strive to translate our findings to the clinical setting.