Selected Publications
Johnson lab members are in bold. Impact factor and citations are listed.
56. Chu KY, Lin Y, Hendel A, Kulpa JE, Brownsey RW, Johnson JD†. ATP-citrate lyase reduction mediates palmitate-induced apoptosis in pancreatic beta-cells. Journal of Biological Chemistry. EPub. August 7, 2010. IF4.3/C0.
55. Bernal-Mizrachi E, Cras-Méneur C, Johnson JD, Permutt MA. Transgenic overexpression of active calcineurin in beta-cells results in decreased beta-cell mass and hyperglycemia in mice. PLos One EPub August 3, 2010. IF4.3/C0.
54. Szabat, M, Johnson, JD†, Piret JM. 2010. Reciprocal modulation of adult beta-cell maturity by activin A and follistatin. Diabetologia. Accepted March 22, 2010. IF6.4/C0.
53. Wang F, Wang Y, Kim M, Puthanveetil P, Ghosh S, Luciani DS, Johnson JD, Abrahani A, Rodrigues B. 2010. Glucose-induced endothelial heparanase secretion requires cortical and stress actin reorganization. Diabetes. 87:127-36. Epub 2010 Feb 17. IF9.0/C0
52. Hutton MJH, Soukhatcheva G, Johnson JD, Verchere CB. Role of the TLR signalling molecule TRIF in beta-cell function and glucose homeostasis. Islets. Accepted January 14, 2010. IFunknown/C0.
51. Alejandro EU, Kalynyak TB, Taghizadeh T, Gwiazda KS, Berring EK, Jacob KJ, Johnson JD†. Insulin activates Erk via Raf-1 and NAADP-dependent calcium signals in pancreatic beta-cells. Accepted in Endocrinology Nov 16, 2009.
50. Fujimoto K, Hanson PT, Tran H, Ford EL, Han Z, Johnson JD, Levine B, Schimdt B, Wice BM, Polonsky KS. 2009. Autophagy regulates pancreatic beta cell death in response to Pdx1 deficiency and nutrient deprivation. Journal of Biological Chemistry. Epub August 4, 2009.
49. Johnson JD†, Otani K, Bell GI, Polonsky KS. 2009. Impaired insulin exocytosis in transgenic mice over-expressing calpastatin in pancreatic beta-cells. In press in lslets August 4, 2009.
48. Kewalramani G, Puthanveetil P, Wang F, Kim MS, Deppe S, Abrahani A, Luciani DS, Johnson JD, Rodrigues B. 2009. AMP-activated protein kinase confers protection against TNF-alpha induced cardiac cell death. Epub June 12, 2009. Cardiovascular Research.
47. Li J, Johnson JD. 2009. Mathematical models of subcutaneous injection of insulin analogues: A mini-review. Discrete and Continuous Dynamical Systems – Series B. Accepted May 2. IF0.9/C0.
46. Johnson JD†, Ao Z, Ao P, Li H, Dai L, He Z, Tee M, Potter KJ, Meloche RM, Thompson DM, Verchere CB, Warnock GL. 2009. Different effects of FK506, rapamycin, and mycophenolate mofetil on glucose-stimulated insulin release and apoptosis in human islets. Cell Transplantation. Epub April 10, 2009. IF3.9/C0.
45. Gwiazda K, Yang TB, Lin Y, Johnson JD†. 2009. Effects of palmitate on ER and cytosolic Ca2+ homeostasis in b-cells. American Journal of Physiology. Accepted Jan 10, 2009. IF4.1/C0.
*44. Szabat M, Luciani DS, Piret J, Johnson JD†. 2008 Maturation of adult beta-cells revealed using a Pdx1/Insulin dual reporter lentivirus. Endocrinology. Epub December 3, 2008. IF4.7/C0.
*43. Warnock GL, Thompson DM, Meloche RM, Shapiro RJ, Ao Z, Keown P, Johnson JD, Verchere CB, Partovi N, Begg IS, Fung M, Kozak SE, Tong SO, Al Ghofaili KM, Harris C. 2008. A Multi-Year Analysis of Islet Transplantation Compared With Intensive Medical Therapy on Progression of Complications in Type 1 Diabetes. Transplantation. 16: In Press. IF4.0/C0.
*42. Luciani DS, Gwiazda K, Yang TL, Kalynyak TB, Bychkivska Y, Jeffrey KD, Frey MHZ, Sampaio AV, Underhill TM, Johnson JD†. Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and b-cell death. Diabetes. E-pub. Nov 27, 2008. IF8.3/C1.
41. Johnson JD†. 2008. Proteomic identification of carboxypeptidase E connects lipid-induced beta-cell apoptosis and dysfunction in type 2 diabetes. Invited review for Cell Cycle. Accepted Nov. 4, 2008. IF3.2/C0. My role – Wrote manuscript.
40. Alejandro EU, Johnson JD†. 2008. Raf-1 kinase in the pancreatic beta-cell. CellSciences. Published Online Oct 2008. Invited review. IF-N/A/C0
39. Chang JP, Johnson JD, Sawisky GR, Grey CL, Mitchell G, Booth M, Volk MM, Parks SK, Thomson E, Goss GG, Klausen C, Habibi HR. 2008. Signal transduction in multifactorial neuroendocrine control of gonadotropin secretion and synthesis in teleosts – studies on the goldfish model. (Invited Review) General and Comparative Endocrinology. E-pub Sept 21. IF2.6/C0.
38. Walia P, Asadi A, Kieffer TJ, Johnson JD, Chanoine J-P. 2008. Ontogeny of ghrelin, obestatin, preproghrelin, and prohormone convertases in rat pancreas and stomach. Pediatric Research. E-pub Sept 3. IF2.9/C0.
37. Wang Y, Huang B, Luciani DS, Wang X, Johnson JD, Proud CG. 2008. Rheb activates protein synthesis and growth in adult rat cardiomyocytes. Journal of Molecular and Cellular Cardiology. 45: 812-20. Epub 2008 Aug 3. IF5.2/C0.
*36. Jeffrey KD, Alejandro EU, Luciani DS, Kalynyak TB, Hu X, Li H, Lin Y, Townsend RR, Polonsky KS, Johnson JD†. 2008. Carboxypeptidase E mediates palmitate-induced beta-cell ER-stress and apoptosis. Proc. Natl. Acad. Sci. USA. (Track II). Jun 17;105(24):8452-7. Epub 2008 Jun 11. IF10.2/C6.
35. Johnson JD†, Alejandro EU. Control of Pancreatic Beta-cell Fate by Insulin Signaling: The Sweet Spot Hypothesis. Cell Cycle. Invited review. Published online March 3, 2008. 7(10). IF3.2/C0.
*34. Dror V, Kalynyak TB, Bychkivska Y, Frey MHZ, Tee M, Jeffrey KD, Nguyen V, Luciani DS, Johnson JD†. 2008. Glucose and ER channels regulate HIF1b via presenilin1 in pancreatic b-cells. Journal of Biological Chemistry. Published online Jan 4, 2008. 283:9909-16. IF5.8/C3.
*33. Beith JL, Alejandro EU, Johnson JD†. 2008. Insulin stimulates primary β-cell proliferation via raf-1 kinase. Endocrinology. 149:2251-60. IF4.7/C7.
*32. Alejandro EU, Johnson JD†. 2008. Inhibition of Raf-1 alters multiple downstream pathways to induce pancreatic b-cell apoptosis. Journal of Biological Chemistry. Jan 25;283(4):2407-17. Epub 2007 Nov 15. IF5.8/C3.
*31. Dror V, Nguyen V, Walia P, Kalynyak TB, Hill JA, Johnson JD†. 2007. Notch signalling suppresses apoptosis in adult pancreatic islet cells. Diabetologia 50:2504-15. IF5.2/C5.
30. Luciani DS, Ao P, Hu X, Warnock GL, Johnson JD†. 2007. The Mitochondrial Na+/Ca2+ Exchange Inhibitor CGP-37157 Impairs Voltage-gated Ca2+ Influx and Insulin Secretion in Human and Mouse beta-cells. European Journal of Pharmacology. 576:18-25.IF2.5/C3.
29. Warnock GL, Liao T, Wang X, Ou D, Ao Z, Johnson JD, Verchere CB, Thompson D. 2007. An Odyssey of Islet Transplantation for Therapy of Type 1 Diabetes. World Journal of Surgery. Aug;31(8):1569-76. Epub 2007 Jun 12. IF1.8/C0.
28. Johnson JD†. 2007. Pancreatic β-cell apoptosis in maturity onset diabetes of the young. (Invited review). Canadian Journal of Diabetes. 31:67-74. No IF/C1.
27. Brunham LR, Kruit JK, Pape TD, Timmins JM, Reuwer AQ, Vasanji Z, Marsh BJ, Johnson JD, Parks JS, Verchere CB, Hayden MR. 2007. ß-Cell ABCA1 Influences Insulin Secretion, Glucose Homeostasis and Response to Thiazolidinedione Treatment. Nature Medicine. 13: 230-7. Published online February 18. IF28.8/C26.
*26. Johnson JD†, Bernal-Mizrachi E, Alejandro E, Han Z, Kalynyak T, Li H, Beith JL, Gross J, Warnock GL, Townsend RR, Permutt MA, Polonsky KS. 2006. Insulin protects islets from apoptosis via pdx-1 and specific changes in the human islet proteome. Proc. Natl. Acad. Sci. USA. (Track II).103: 19575-80. IF10.2/C23.
*25. Johnson JD†, Bernal-Mizrachi E, Ford EL, Han Z, Kusser KL, Luciani DS, Tran H, Randall TD, Lund FE, Polonsky KS. 2006. Increased apoptosis and suppressed insulin signaling in Cd38 null islets. Diabetes. 55: 2737-2746. IF8.0/C12.
24. Wideman RD, Yu ILY, Webber TD, C. Verchere CB, Johnson JD, Cheung AT, Kieffer TJ. 2006. Improving Function and Survival of Pancreatic Islets by Endogenous Production of GLP-1. Proc. Natl. Acad. Sci. USA. (Track II). 103: 13468–13473. IF10.2/C10.
*23. Luciani DS, Johnson JD†. 2005. Acute effects of insulin on dispersed cells from transplantable human islets. Molecular and Cellular Endocrinology. 241: 88-98. IF2.7/C9.
22. Warnock GL, Meloche RM, Thompson D, Shapiro J, Fung M, Ao Z, Ho S, He Z, Dai LJ, Young L, Blackburn L, Kozak S, Kim P, Al-Adra D, Johnson JD, Liao T, Elliott T, Verchere CB. 2005. Novel strategies for human pancreatic islet isolation and transplantation. Archives of Surgery. 140:735-44. IF3.0/C21.
21. Johnson JD†, Chang JP. 2005. Calcium buffering activity of mitochondria controls basal growth hormone secretion and modulates specific neuropeptide signaling. Cell Calcium. 37:573-81. IF4.9/C7.
20. Ohsugi M, Cras-Méneur C, Zhou Y, Bernal-Mizrachi E, Johnson JD, Luciani DS, Polonsky KS, Permutt MA. 2005. Reduced expression of the insulin receptor in mouse insulinoma (MIN6) cells reveals multiple roles of insulin signaling in gene expression, proliferation, insulin content and secretion. Journal of Biological Chemistry. 280, 4992-5003. IF5.8/C31.
19. Bernal E, Fatrai S, Johnson JD, Ohsugi M, Otani K, Han Z, Polonsky KS, Permutt MA. 2004. Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced AKT activity in pancreatic islet beta-cells. Journal of Clinical Investigation. 114: 928-936. IF15.0/C47.
*18. Johnson JD, Han Z, Otani K, Ye H, Zhang Y, Wu H, Horikawa Y, Misler S, Bell GI, Polonsky KS. 2004. RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets. Journal of Biological Chemistry 279: 24794-24802. IF5.8/C47.
*17. Johnson JD†, Kuang S, Misler S, Polonsky KS. 2004. Ryanodine receptors in human pancreatic beta-cells: Localization and effects on insulin secretion. FASEB J. 10.1096/fj.03-1280fje. IF7.0/C22.
*16. Johnson JD, Ahmed NT, Luciani DS, Han Z, Tran H, Fujita J, Misler S, Edlund H, Polonsky KS. 2003. Increased islet apoptosis in PDX-1+/- mice. Journal of Clinical Investigation. 111:1147-1160. IF15.0/C119.
15. Koster JC, Remedi M, Flagg T, Johnson JD, Markova K, Marshall BA, Nichols CG. 2002. Targeted Suppression of b-cell KATP Channels Induces Persistent Hyperinsulinism. Proc. Natl. Acad. Sci. USA. (Track II). 99:16992-7. IF10.2/C21.
14. Johnson JD, Klausen C, Habibi HR, Chang JP. 2003. A GnRH-insensitive, thapsigargin-sensitive Ca2+ store reduces basal gonadotropin exocytosis and gene expression: Comparison with agonist-sensitive Ca2+ stores. J Neuroendocrinology 15:204-14. IF2.9/C6.
*13. Johnson, JD†, Misler S. 2002. Nicotinic acid adenine dinucleotide phosphate-sensitive calcium stores initiate insulin signaling in human b-cells. Proc. Natl. Acad. Sci. USA (Track II). 99: 14566-14571. IF10.2/C55.
12. Johnson JD, Chang JP. 2002. Agonist-specific and sexual stage-dependent inhibition of GnRH-stimulated gonadotropin and growth hormone release by ryanodine: Relationship to sexual stage-dependent caffeine-sensitive hormone release. J Neuroendocrinology 14: 144-155. IF2.9/C14.
11. Johnson JD, Klausen C, Habibi HR, Chang JP. 2002. Function-specific Ca2+ stores selectively regulate growth hormone secretion, storage and mRNA. Am J Physiol. Endo. 282: E810-E819. IF4.4/C13.
10. Johnson JD, Wong CJH, Yunker WK, Chang JP. 2001. Caffeine stimulated GTH-II release involves Ca2+ stores with novel properties. Am J Physiol. Cell 282: C635-C645. IF3.9/C7.
9. Wong CJH, Kwong P, Johnson JD, Yunker WK, Chang JP. 2001. Modulation of GTH-II release by K+ channel blockers in goldfish gonadotropes: a novel stimulatory action of 4-aminopyridine J Neuroendocrinol.13: 915-958. IF2.9/C3.
8. Chang JP, Wirachowsky NR, Kwong P, Johnson JD. 2001. PACAP stimulation of gonadotropin-II secretion in goldfish pituitary cells: mechanisms of action and interaction with gonadotropin-releasing hormone. J Neuroendocrinology, 13: 540-550. IF2.9/C22.
7. Wong CJH, Johnson JD*, Yunker WK, Chang JP. 2001. Caffeine stores and dopamine differentially require Ca2+ channels to stimulate hormone secretion. Am J Physiol Integrative 280: R494-R503. * co-first author. IF3.8/C13.
6. Wirachowsky NR, Kwong P, Yunker WK, Johnson JD, Chang JP. 2000. Mechanisms of action of pituitary adenylate cyclase-activating polypeptide (PACAP) on growth hormone release from dispersed goldfish pituitary cells. Fish Physiology Biochemistry 23: 201-214. IF0.5/C11.
5. Johnson JD, Van Goor F, Jobin, RM, Wong CJH, Chang JP. 2000. Agonist-specific Ca2+ signaling systems, composed of multiple intracellular Ca2+ stores, regulate gonadotropin secretion. Molecular and Cellular Endocrinology 170: 15-29. IF2.7/C17.
4. Johnson, JD, Chang, JP. 2000. Novel, thapsigargin-insensitive intracellular Ca2+ stores control growth hormone release from goldfish pituitary cells. Molecular and Cellular Endocrinology. 165: 139-150. IF2.7/C23.
3. Chang JP, Johnson JD, Van Goor F, Wong CJH, Yunker WK, Uretsky AD, Jobin RM, Wong AOL, Goldberg JI. 2000. Signal transduction mechanisms mediating secretion in goldfish gonadotropes and somatotropes. Biochemistry and Cell Biology. 78: 139-153. IF2.8/C44.
2. Johnson JD, Chang JP. 2000. Function- and agonist-specific Ca2+ signalling: the requirement for and mechanism of spatial and temporal complexity in Ca2+ signals. Biochemistry & Cell Biology 78: 217-240. IF2.8/C28.
1. Johnson JD, Van Goor F, Wong CJH, Goldberg JI, Chang JP. 1999. Two endogenous gonadotropin-releasing hormones generate dissimilar Ca2+ signals in identified goldfish gonadotropes. General & Comparative Endocrinology. 116: 178-191. IF2.2/C22.
