WHO WE ARE
The Diabetes Research Group holds a Journal Club on Thursday mornings at 9:00 AM in the Life Sciences Centre Room 5650 (Western lunch pod). All the trainees that are supervised by members of the Diabetes Research Group rotate to present a recently published paper with high impact in the field of diabetes. The presentation will contain sufficient background information and the discussions are open to all attendees. Please contact Dr. Timothy J. Kieffer if you are interested in participating.
UPCOMING PRESENTATION
9:00 AM in the Life Sciences Centre Room 5650 (Western lunch pod).
Date | Presenter | Author | Journal | Title |
November 26, 2020 | Dr. Sadaf Farooqi Guest Lecture | The genetic basis of obesity and thinness |
PAST PRESENTATIONS
November 2020 | ||||
Date | Presenter | Author | Journal | Title |
November 19, 2020 | Dr. Shenghui Liang | Peterson et al. (Douglas A. Melton’s group) | Nature Communications | A method for the generation of human stem cell-derived alpha cells |
November 12, 2020 | No meeting (VDRD) | |||
November 5, 2020 | Jamie Chu | Karakose et al. (Andrew F. Stewart’s group) | Nature Communications | Aberrant methylation underlies insulin gene expression in human insulinoma |
June 2020 | ||||
Date | Presenter | Author | Journal | Title |
June 25, 2020 | Daemon Cline | Colli et al. (Décio L. Eizirik’s group) | Nature Communications | An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells |
June 18, 2020 | Jason Millington | van Dam et al. (Helena M. Cochemé’s group) | Cell Metabolism | Sugar-Induced Obesity and Insulin Resistance Are Uncoupled from Shortened Survival in Drosophila |
June 11, 2020 | Dr. Jelena Kolic | Camunas-Soler et al. (Patrick MacDonald’s group) | Cell Metabolism | Patch-Seq Links Single-Cell Transcriptomes to Human Islet Dysfunction in Diabetes |
June 4, 2020 | Dr. Jia Zhao | Velazco-Cruz et al. (Jeffery R. Millman’s group) | Cell Reports | SIX2 regulates human β cell differentiation from stem cells and functional maturation in vitro |
May 2020 | ||||
Date | Presenter | Author | Journal | Title |
May 28, 2020 | Jamie Chu | Ramos-Rodríguez et al. (Lorenzo Pasquali’s group) | Nature Genetics | The impact of proinflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes |
May 21, 2020 | No meeting | Vancouver Diabetes Research Day Discussion | ||
May 14, 2020 | Stella Baehring | Mazucanti et al (Josephine M. Egan’s group) | JCI Insight | Release of insulin produced by the choroid plexus is regulated by serotonergic signaling |
May 7, 2020 | Queenie Hui | Omar-Hmeadi et al (Sebastian Barg’s group) | Nature Communications | Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes |
April 2020 | ||||
Date | Presenter | Author | Journal | Title |
April 30, 2020 | No meeting | |||
April 23, 2020 | Nelly Saber | Hughes et al (David W. Piston’s group) | PNAS | Primary cilia control glucose homeostasis via islet paracrine interactions |
April 16, 2020 | Dr. Søs Skovsø |
Raun et al (Lykke Sylow’s group) | Nature Communications | Housing temperature influences exercise training adaptations in mice |
April 9, 2020 | Annie Zhang | Srikantan et al (Patricia Dahia’s group) | Nature Communications | The tumor suppressor TMEM127 regulates insulin sensitivity in a tissue-specific manner |
April 2, 2020 | Mitchell Braam | Wang et al (Yi Zeng’s group) | Cell | Long-Term Expansion of Pancreatic Islet Organoids from Resident Procr+ Progenitors |
March 2020 | ||||
Date | Presenter | Author | Journal | Title |
March 26, 2020 | No meeting | |||
March 19, 2020 | No meeting | |||
March 12, 2020 | Dr. Shogo Ida | Forbes et al (John Campbell’s group) | Science Translational Medicine | Human umbilical cord perivascular cells improve human pancreatic islet transplant function by increasing vascularization |
March 5, 2020 | Priye Iworima | Hogrebe et al (Jeffrey Millman’s group) | Nature Biotechnology | Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells |
February 2020 |
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Date | Presenter | Author | Journal | Title |
February 27, 2020 | Alice Wang | Kim et al (Hail Kim’s group) | Diabetes | PRMT1 Is Required for the Maintenance of Mature β-Cell Identity |
February 20, 2020 | Dr. Evgeniy Panzhinskiy | Nakayasu et al (Carmella Evans-Molina’s group) | Cell Metabolism | Comprehensive Proteomics Analysis of Stressed Human Islets Identifies GDF15 as a Target for Type 1 Diabetes Intervention |
February 13, 2020 | No meeting | |||
February 6, 2020 | Dr. Shenghui Liang | Mochida et al. (Taro Toyoda’s group) | Diabetes | Insulin-deficient diabetic condition upregulates insulin secreting capacity of human iPSC-derived pancreatic endocrine progenitor cells after implantation in mice |
January 2020 |
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Date | Presenter | Author | Journal | Title |
January 30, 2020 | Lianna Wat | Penniman et al. (Brian T O’Neill’s group) | Molecular Metabolism | Loss of FoxOs in muscle reveals sex-based differences in insulin sensitivity but mitigates diet-induced obesity |
January 23, 2020 | Professor Jochen Lang | |||
January 9, 2020 | Jason Millington | Oh et al. (Greg SB Suh’s group) | Nature | A glucose-sensing neuron pair regulates insulin and glucagon in Drosophila |
December 2019 |
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Date | Presenter | Author | Journal | Title |
December 05, 2019 | Jamie Chu | Taddeo et al. (Orian Shirihai’s group) | Diabetes | Mitochondrial proton leak regulated by Cyclophilin D elevates insulin secretion in islets at non-stimulatory glucose levels |
November 2019 |
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Date | Presenter | Author | Journal | Title |
November 28, 2019 | Queenie Hui | Recino et al. (Maja Wållberg’s group) | bioRxiv | GLP-1R is downregulated in beta cells of NOD mice and T1D patients |
November 07, 2019 | Stella Baehring | Chow et al. (Karl Herrup’s group) | Nature Neuroscience | Age-related hyperinsulinemia leads to insulin resistance in neurons and cell-cycle-induced senescence |
October 2019 |
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Date | Presenter | Author | Journal | Title |
October 31, 2019 | Priye Iworima | Lebreton et al. (Ekaterine Berishvili’s group) | Nature Communications | Insulin-producing organoids engineered from islet and amniotic epithelial cells to treat diabetes |
October 24, 2019 | Peter Overby | Verhagen et al. (Mark Peakman’s group) | Diabetologia | Proinsulin peptide promotes autoimmune diabetes in a novel HLA-DR3-DQ2-transgenic murine model of spontaneous disease |
October 17, 2019 | Dr. Søs Skovsø | Singer et al. (Lori Sussel’s group) | Cell Metabolism | The Long Noncoding RNA Paupar Modulates PAX6 Regulatory Activities to Promote Alpha Cell Development and Function |
October 10, 2019 | Anni Zhang | Chung et al. (Mandar Deepak Muzumdar’s group) | BioRxiv | Endocrine-exocrine signaling drives obesity-associated pancreatic ductal adenocarcinoma |
October 03, 2019 | Mitchell Braam | Kuo et al. (Domenico Accili’s group) | PNAS | Identification of C2CD4A as a human diabetes susceptibility gene with a role in β cell insulin secretion |
September 2019 |
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Date | Presenter | Author | Journal | Title |
September 26, 2019 | Dr. Shogo Ida | Mani et al. (JM Zigman’s Group) | JCI | LEAP2 changes with body mass and food intake in humans and mice |
September 12, 2019 | Dr. Cara Ellis | Drigo et al. (MW Hetzer’s Group) | BioRxiv | Aging of human endocrine pancreatic cell types is heterogeneous and sex-specific |
September 5, 2019 | Alice Wang | Ramadori et al. (R Coppari’s Group) | Nature Communications | S100A9 extends lifespan in insulin deficiency |
August 2019 |
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Date | Presenter | Author | Journal | Title |
August 29, 2019 | Dr. Evgeniy Panzhinskiy | Cardenas-Diaz et al. (Paul Gadue’s Group) | Cell Stem Cell | Modeling Monogenic Diabetes using Human ESCs Reveals Developmental and Metabolic Deficiencies Caused by Mutations in HNF1A |
August 22, 2019 | Dr. Shenghui Liang | Jaafar et al. (Anil Bhushan’s Group) | JCI | mTORC1-to-AMPK switching underlies β cell metabolic plasticity during maturation and diabetes |
August 15, 2019 | Lianna Wat | Villanueva et al. (Girish C. Melkani’s Group) | Nature Communications | Time-restricted feeding restores muscle function in Drosophila models of obesity and circadian-rhythm disruption |
August 8, 2019 | Dillon Jevon | Capozzi et al. (Jonathan E. Campbell’s Group) | JCI Insight | Glucagon lowers glycemia when β-cells are active |
August 1, 2019 | Dr. Maria Glavas | Zhu et al. (He-Feng Huang’s Group) | Diabetes | Insulin Therapy for Gestational Diabetes Does Not Fully Protect Offspring from Diet-Induced Metabolic Disorders |
July 2019 |
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Date | Presenter | Author | Journal | Title |
July 25, 2019 | Jason Millington | Texada et al. (KF Rewitz’s Group) | Nature Communications | A fat-tissue sensor couples growth to oxygen availability by remotely controlling insulin secretion |
July 18, 2019 | Howard Cen | Rui Jia & Juan S. Bonifacino | Molecular Cell | Lysosome Positioning Influences mTORC2 and AKT Signaling |
July 11, 2019 | Peter Overby | Jiang et al. (KKY Cheng’s Group) | Diabetologia | APPL1 prevents pancreatic beta cell death and inflammation by dampening NFκB activation in a mouse model of type 1 diabetes |
July 4, 2019 | Queenie Hui | Aguayo-Mazzucato et al. (S Bonner-Weir’s Group) | Cell Metabolism | Acceleration of β Cell Aging Determines Diabetes and Senolysis Improves Disease Outcomes |
June 2019 |
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Date | Presenter | Author | Journal | Title |
June 13, 2019 | Priye Iworima | Veres et al. (D Melton’s Group) | Nature | Charting cellular identity during human in vitro β-cell differentiation |
June 06, 2019 | Dr. Søs Skovsø | Dirice et al. (R Kulkarni’s Group) | Nature Metabolism | Increased β-cell proliferation before immune cell invasion prevents progression of type 1 diabetes |
May 2019 |
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Date | Presenter | Author | Journal | Title |
May 23, 2019 | Mitchell Braam | Pepper et al. (J Shapiro’s Group) | Diabetes | Posttransplant Characterization of Long-term Functional hESC-Derived Pancreatic Endoderm Grafts |
May 16, 2019 | Dr. Cara Ellis | Sharon et al. (D Melton’s Group) | Cell | A Peninsular Structure Coordinates Asynchronous Differentiation with Morphogenesis to Generate Pancreatic Islets |
May 9, 2019 | Diego Botezelli | Grandoch et al. (J Fischer’s Group) | Nature Metabolism | 4-Methylumbelliferone improves the thermogenic capacity of brown adipose tissue |
April 2019 |
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Date | Presenter | Author | Journal | Title |
April 18, 2019 | Nelly Saber | Nair et al. (Matthias Hebrok’s Group) | Nature Cell Biology | Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells |
April 11, 2019 | Dr. Evgeniy Panzhinskiy | Thompson et al. (Anil Bhushan’s Group) | Cell Metabolism | Targeted Elimination of Senescent Beta Cells Prevents Type 1 Diabetes |
March 2019 |
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Date | Presenter | Author | Journal | Title |
March 28, 2019 | Dr. Sandra Pereira | Li et al. (M Klingenspor’s Group) | Cell | Secretin-Activated Brown Fat Mediates Prandial Thermogenesis to Induce Satiation |
March 14, 2019 | Dillon Jevon | Strollo et al. (A Nissim’s Group) | Diabetes/Metabolism Research and Reviews | Antibodies to oxidized insulin improve prediction of type 1 diabetes in children with positive standard islet‐autoantibodies |
March 7, 2019 | Howard Cen | Lam et al. (J Kushner’s Group) | Diabetes | Low-Level Insulin Content Within Abundant Non-β Islet Endocrine Cells in Long-standing Type 1 Diabetes |
February 2019 |
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Date | Presenter | Author | Journal | Title |
February 28, 2019 | Dr. Maria Glavas | Furuyama et al. (P Herra’s Group) | Nature | Diabetes relief in mice by glucose-sensing insulin-secreting human alpha-cells |
February 21, 2019 | Jason Millington | Eleonora Meschi, Pierre Léopold, & Renald Delanoue | Developmental Cell | An EGF-Responsive Neural Circuit Couples Insulin Secretion with Nutrition in Drosophila |
February 14, 2019 | Dr. Jelena Kovic | Knudsen et al. (P Rorsman’s Group) | Cell Metabolism | Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production |
February 07, 2019 | Peter Overby | Ying et al. | Cell Metabolism | Expansion of Islet-Resident Macrophages Leads to Inflammation Affecting b Cell Proliferation and Function in Obesity |
January 2019 |
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Date | Presenter | Author | Journal | Title |
January 31, 2019 | Dr. Honey Modi | Ogrodnik et al. (D Jurk’s Group) | Cell Metabolism | Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis |
January 24, 2019 | Priye Iworima | Velazco-Cruz et al. (J. R Millman Group) | Stem Cell Reports | Acquisition of Dynamic Function in Human Stem Cell-Derived Beta Cells |
January 10, 2019 | Anni Zhang | Tao et al. (S. Jia Group) | Diabetes | Haploinsufficiency of Insm1 Impairs Postnatal Baseline β-Cell Mass |
December 2018 |
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Date | Presenter | Author | Journal | Title |
December 13, 2018 | Mitchell Braam | Mamidi et al. (H Semb’s group) | Nature | Mechanosignalling via integrins directs fate decisions of pancreatic progenitors |
December 6, 2018 | Diego Botezelli | |||
October 2018 |
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October 25, 2018 | Dr. Cara Ellis | Guay et al. (R. Regazzi’s Group) | Cell Metabolism | Lymphocyte-Derived Exosomal MicroRNAs Promote Pancreatic β Cell Death and May Contribute to Type 1 Diabetes Development |
October 11, 2018 | Lianna Wat | Moraru et al. (A.A. Teleman’s Group) | Cell Metabolism | Elevated Levels of the Reactive Metabolite Methylglyoxal Recapitulate Progression of Type 2 Diabetes |
October 4, 2018 | Adam Ramzy | Xu et al. (F. Mauvais-Jarvis’s Group) | Cell Metabolism | Estrogens Promote Misfolded Proinsulin Degradation to Protect Insulin Production and Delay Diabetes |
August 2018 |
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August 30, 2018 | Dr. Jelena Kolic | Hu et al. (J.R. Speakman’s Group) | Cell Metabolism | Dietary Fat, but Not Protein or Carbohydrate, Regulates Energy Intake and Causes Adiposity in Mice |
August 23, 2018 | Michelle Kwon | Zang al. (A Eichmann’s Group) | Science | Lacteal junction zippering protects against diet-induced obesity |
August 16, 2018 | Søs Skovsø | Tayloret al. (M.E.J. Lean’s Group) | Cell Metabolism | Remission of human type 2 diabetes requires decrease in liver and pancreas fat content but is dependent upon the capacity for beta cell recovery |
August 9, 2018 | Anni Zhang | Hopkins et al. (LC. Cantley’s Group) | Nature | Suppression of insulin feedback enhances the efficacy of PI3K inhibitors |
August 2, 2018 | Mitchell Braam | Amin et al. (S. Chen’s Group | Nature Communications | Discovery of a drug candidate for GLIS3-associated diabetes |
July 2018 |
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July 19, 2018 | Nelly Saber | Navarro et al. (Mauvais-Jarvis’s Group) | JCI Insight | Androgen excess in pancreatic beta cells and neurons predisposes female mice to type 2 diabetes |
July 12, 2018 | Sepehr Kamal | Xin et al. (Gramada Group) | Diabetes | Pseudotime Ordering of Single Human β-Cells Reveals States of Insulin Production and Unfolded Protein Response |
July 5, 2018 | Chiara Toselli | Millership et al. (Withers Group) | JCI | Neuronatin regulates pancreatic beta-cell insulin content and secretion |
May 2018 |
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May 31, 2018 | Lianna Wat | Catterson et al. (L Partridge’s Group) | Current Biology | Short-Term, Intermittent Fasting Induces Long-Lasting Gut Health and TOR-Independent Lifespan Extension |
May 24, 2018 | Jason Millington | Roth et al. (ML Bland’s Group) | Cell Reports | Innate Immune Signaling in Drosophila Blocks Insulin Signaling by Uncoupling PI(3,4,5)P3 Production and Akt Activation |
May 17, 2018 | Dr. Honey Modi | Lu et al. (JA Pospisilik’s Group) | Cell Metabolism | The Polycomb-Dependent Epigenome Controls β Cell Dysfunction, Dedifferentiation, and Diabetes |
May 10, 2018 | Adam Ramzy | Puri et al. (M Hebrok’s Group) | Nature Communications | Replication confers β cell immaturity |
May 3, 2018 | Dr. Helena Kolic | Bauer et al. (TKT Lam’s Group) | Cell Metabolism | Metformin Alters Upper Small Intestinal Microbiota that Impact a Glucose-SGLT1-Sensing Glucoregulatory Pathway |
March 2018 |
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March 29, 2018 | Sepehr Kamal | Riddle et al. (N Rohner’s Group) | Nature | Insulin resistance in cavefish as an adaptation to a nutrient-limited environment |
March 22, 2018 | Michelle Kwon | Rodriguez-Diaz et al. (PO Berggren’s Group) | Cell Metabolism | Paracrine Interactions within the Pancreatic Islet Determine the Glycemic Set Point |
March 15, 2018 | Jose Diego Botezelli | Charles et al. (GS Hotamisligil’s Group) | Cell Reports | Uncoupling of Metabolic Health from Longevity through Genetic Alteration of Adipose Tissue Lipid- Binding Proteins |
March 8, 2018 | Mitchell Braam | Xiao et al. (GK Gittes Group) | Cell Stem Cell | Endogenous Reprogramming of Alpha Cells into Beta Cells, Induced by Viral Gene Therapy, Reverses Autoimmune Diabetes |
March 1, 2018 | Nelly Saber | Gandasi et al. (S. Barg’s Group | Cell Metabolism | Glucose-dependent granule docking limits insulin secretion and is decreased in human type 2 diabetes |
February 2018 |
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February 22, 2018 | Dr. Evgeniy Panshinskiy | Bartelt et al. | Nature Medicine | Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity |
February 8, 2018 | Peter Overby | Ramirez et al. | Cell Metabolism | Mitochondrial Dynamics Mediated by Mitofusin 1 Is Required for POMC Neuron Glucose-Sensing and Insulin Release Control |
February 1, 2018 | Lianna Watt | Beshel et al. | Cell Metabolism | Leptin Analog Locally Produced in the Brain Acts via a Conserved Neural Circuit to Modulate Obesity-Linked Behaviors in Drosophila |
January 2018 |
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December 2017 |
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December 14, 2017 | Jason Millington | Yan et al.(R. Jiao’s group) | Developmental Cell | HDAC6 Suppresses Age-Dependent Ectopic Fat Accumulation by Maintaining the Proteostasis of PLIN2 in Drosophila |
December 7, 2017 | Dr. Honey Modi | Bozadjieva et al. (E. Bernal-Mizrachi’s group) | J Clin. Investigation | Loss of mTORC1 signaling alters pancreatic α cell mass and impairs glucagon secretion |
November 2017 |
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November 30, 2017 | Dr. Jelena Kolic | Softic et al.(C.R. Kahn’s group) | J Clin. Investigation | Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signalling |
November 23, 2017 | Dr. Cara Ellis | van der Meulen et al, (M.O. Huising’s group) | Cell Metabolism | Artemether Does Not Turn α Cells into β Cells |
November 16, 2017 | Howard Cen | Zhao et al, (G. Bu’s group) | Neuron | Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes |
November 9, 2017 | Dr. Søs Skovsø | Konishi et al, (CR Kahn’s group) | PNAS | Endothelial insulin receptors differentially control insulin signaling kinetics in peripheral tissues and brain of mice |
November 2, 2017 | Anni Zhang | Langlet et al,(D. Accili’s Group) | Cell | Selective Inhibition of FOXO1 Activator/Repressor Balance Modulates Hepatic Glucose Handling |
October 2017 |
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October 19, 2017 | Connie Leung | Shin et al. (L. Yu’s group) | Cell Metabolism | Lipolysis in Brown Adipocytes Is Not Essential for Cold-Induced Thermogenesis in Mice |
October 5, 2017 | Michelle Kwon | Hsu et al. (B.B. Allan’s group) | Nature | Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15 |
August 2017 |
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July 2017 |
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July 27, 2017 | Dr. Honey Modi | Blandino-Rosano et al. (E. Bernal-Mizrachi’s group) | Nature Communications | Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing |
July 13, 2017 | Dr. Jelena Kolic | Ni et al, (Q. Wang’s group) | Nature Communications | Raptor regulates functional maturation of murine beta cells |
July 6, 2017 | Dr. Cara Ellis | Rodnoi et al, (S. Dhawan’s group) | JCI Insight | Neuropeptide Y expression marks partially differentiated β cells in mice and humans |
June 2017 |
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June 29, 2017 | Dr. Søs Skovsø | Loh et al, (H. Herzog’s group) | Molecular Metabolism | Insulin controls food intake and energy balance via NPY neurons |
June 22, 2017 | Howard Cen | Cai et al, (R. Kahn’s group) | Nature Communications | Domain-dependent effects of insulin and IGF-1 receptors on signaling and gene expression |
June 15, 2017 | Anni Zhang | Axelsson et al, (A.H. Rosengren’s group) | Nature Communications | Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes |
June 8, 2017 | Chiara Toselli | Zhang et al, (Dongsheng Cai’s group) | Cell Metabolism | Astrocytic Process Plasticity and IKKβ/NF-κB in Central Control of Blood Glucose, Blood Pressure, and Body Weight |
June 1, 2017 | Connie Leung | Varela et al,(Tamas L. Horvath Group) | Diabetes | Endothelial HIF-1a Enables Hypothalamic Glucose Uptake to Drive POMC Neurons |
May 2017 |
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May 18, 2017 | Dr. Adriana Migliorini | Migliorini et al. | Beta-cells are not all the same: Identification of proliferative and mature beta-cells in the islet of Langerhans | |
May 11, 2017 | Michelle Kwon (Kieffer Lab) | Fan et al. (Ronald Evan’s group) | Cell Reports | PPARδ Promotes Running Endurance by Preserving Glucose |
May 4, 2017 | Dr. Melissa Page (Johnson Lab) | Aguayo-Mazzucato et al. (Susan Bonner-Weir’s group) | Cell Metabolism | β Cell Aging Markers Have Heterogeneous Distribution and Are Induced by Insulin Resistance |
April 2017 |
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April 27, 2017 | Dr. Evgeniy Panshinskiy (Johnson Lab) | Morita et al. (Feroz Papa’s group) | Cell Metabolism | Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes |
April 13, 2017 | Nina Quiskamp (Kieffer Lab) | Traub et al. (V Makshana’s group) | Cell Reports | Pancreatic α Cell-Derived Glucagon-Related Peptides Are Required for β Cell Adaptation and Glucose Homeostasis |
March 2017 |
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March 30, 2017 | Maria Glavas (Kieffer Lab) | Deng et al. (P Scherer’s group) | Science | An adipo-biliary-uridine axis that regulates energy homeostasis |
March 23, 2017 | Rene Pedroza (Piret Lab) | Berman et al. (A Pileggi’s group) | Diabetes | Bioengineering the Endocrine Pancreas: Intraomental Islet Transplantation Within a Biologic Resorbable Scaffold |
March 16, 2017 | Dr. Suheda Erener (Kieffer Lab) | Thomou et al. (CR Kahn’s group) | Nature | Adipose-derived circulating miRNAs regulate gene expression in other tissues |
March 9, 2017 | Adam Ramzy (Kieffer Lab) | Kracht et al. (BO Roep’s group) | Nature Medicine | Autoimmunity against a defective ribosomal insulin gene product in type 1 diabetes |
March 2, 2017 | Howard Cen (Johnson Lab) | Cheng et al. (VD Longo’s group) | Cell | Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes |
Februrary 2017 |
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February 23, 2017 | Dr. Sandra Pereira (Kieffer Lab) | Jubota et al. (T Kadowaki’s group) | Nature Communications | Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity |
February 16, 2017 | Dr. Davide Pacitti (Kieffer Lab) | Hill et al. (K Guillemin’s group) | eLife | A conserved bacterial protein induces pancreatic beta cell expansion during zebrafish development |
January 2017 |
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January 26, 2017 | Dr. Søs Skovsø (Johnson Lab) | P Li et al. (JM Olefsky’s group) | Cell | Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance |
January 19, 2017 | Dr. Jelena Kovic (Johnson Lab) | M Sakaguchi et al. (CR Kahn’s group) | Cell Metabolism | Adipocyte Dynamics and Reversible Metabolic Syndrome in Mice with an Inducible Adipocyte-Specific Deletion of the Insulin Receptor |
January 12, 2017 | Dr. Cara Ellis (Kieffer Lab) | N Ben-Othman et al. (P Collombat’s group) | Cell | Long-Term GABA Administration Induces Alpha Cell-Mediated Beta-like Cell Neogenesis |
December 2016 |
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December 15, 2016 | Connie Leung (Clee Lab) | AS Williams et al. (DH Wasserman’s group) | Diabetes | Integrin-linked Kinase is Necessary for the Development of Diet-induced Hepatic Insulin Resistance |
December 8, 2016 | Nelly Saber(Kieffer Lab) | MF Brereton et al. (FM Ashcroft’s group) | Nature Communications | Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic beta cells |
December 1, 2016 | Dr. Majid Mojiban (Kieffer Lab) | C Cianciaruso et al. (S Baekkeskov’s group) | Diabetes | Primary human and rat beta cells release the intracellular autoantigens GAD65, IA-2 and proinsulin in exosomes together with cytokine-induced enhancers of immunity |
November 2016 |
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November 24, 2016 | Michelle Kwon (Kieffer Lab) | EE Mulvihill et al. (D Drucker’s group) | Cell Metabolism | Cellular Sites and Mechanisms Linking Reduction of Dipeptidyl Peptidase-4 Activity to Control of Incretin Hormone Action and Glucose Homeostasis/a> |
November 17, 2016 | Dr. Evgeniy Panzhinskiy (Johnson Lab) | YJ Wang et al (K Kaestner’s group) | Cell Metabolism | Single-Cell Mass Cytometry Analysis of the Human Endocrine Pancreas |
November 10, 2016 | Dr. Suheda Erener (Kieffer Lab) | X Wei et al (CF Semenkovichs’s group) | Diabetes | Fatty acid synthesis configures the plasma membrane for inflammation in diabetes |
November 3, 2016 | Jason Lee (Johnson Lab) | T Thayer et al (S Wongs’s group) | Diabetes | Peripheral Proinsulin Expression Controls Low-Avidity Proinsulin-Reactive CD8 T Cells in Type 1 Diabetes |
October 2016 |
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Oct 27, 2016 | Dr. Maria Glavas (Kieffer Lab) | B Finan (TD Muller’s group) | Cell | Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease. |
Oct 13, 2016 | Rene Pedroza (Piret Lab) | L van Gurp (EJP deKoning’s group) | Diabetologia | Sequential intravital imaging reveals in vivo dynamics of pancreatic tissue transplanted under the kidney capsule in mice |
Oct 6, 2016 | Anna D’souza (Kieffer Lab) | N Morton et al (S Horvat’s group) | Nature Medicine | Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness |
September 2016 |
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Sept 29, 2016 | Chiara Toselli (Kieffer Lab) | Y Zhu et al (PE Scherer’s group) | Cell Metabolism | Connexin 43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals |
Sept 22, 2016 | Adam Ramzy (Kieffer Lab) | JY Kim-Muller et al (D Accili’s group) | Nature Communications | Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic β cells in diabetic mice |
Sept 15, 2016 | Dr. Sandra Pereira (Kieffer Lab) | C Garcia-Caceres et al (MH Tschop’s group) | Cell | Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability |
Sept 8, 2016 | Ursula Neumann (Kieffer Lab) | A Nagarajan et al (N Wajapeyee’s group) | Nature Communications | MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels |
Sept 1, 2016 | Dr. Honey Modi (Johnson Lab) | J Lu et al (O Andersson’s group) | The EMBO Journal | IGFBP1 increases β-cell regeneration by promoting α- to β-cell transdifferentiation |
August 2016 |
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August 4, 2016 | Dr. Cara Ellis (Kieffer Lab) | van Bussel et al (JFA Jansen group) | Diabetes | Functional Brain Networks Are Altered in Type 2 Diabetes and Prediabetes: Signs for Compensation of Cognitive Decrements? The Maastricht Study |
July 2016 |
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July 28, 2016 | Nelly Saber (Kieffer Lab) | Johnston et al (DJ Hodson group) | Cell Metabolism | Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose |
July 21, 2016 | Dr. Davide Pacitti (Kieffer Lab) | Dorrell et al (M Grompe group) & Bader et al (H Lickert group) | Nature Communications & Nature | Human islets contain four distinct subtypes of β cells Identification of proliferative and mature β-cells in the islets of Langerhans |
July 14, 2016 | Dr. Suheda Erener (Kieffer Lab) | Scarlett et al (MW Schwartz group) | Nature Medicine | Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents |
July 7, 2016 | Chiara Toselli (Kieffer Lab) | Perry et al (GI Shulman’s group) | Nature | Acetate mediates a microbiome–brain–β-cell axis to promote metabolic syndrome |
June 2016 |
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June 30, 2016 | Dr. Evgeniy Panzhinskiy (Johnson Lab) | Mitchell et al (R. de Cabo’s group) | Cell Metabolism | Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice |
June 23, 2016 | Dr. Majid Mojibian (Kieffer Lab) | Li et al (B.M. Evers’s group) | Nature | An obligatory role for neurotensin in high-fat-diet- induced obesity |
June 16, 2016 | Dr. Nina Quiskamp (Kieffer Lab) | Saxena et al (Fussenegger’s group) | Nature Communications | A programmable synthetic lineage-control network that differentiates human IPSCs into glucose-sensitive insulin-secreting beta-like cells |
June 9, 2016 | Jason Lee (Johnson Lab) | Kodama et al (L. Yu’s group) | Diabetes | Expression-Based Genome-Wide Association Study Links Vitamin D-Binding Protein With Autoantigenicity in Type 1 Diabetes |
May 2016 |
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May 26, 2016 | Rene Pedroza (Piret Lab) | Vegas et al (D. Anderson’s group) | Nature Medicine | Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice |
May 19, 2016 | Dr. Maria Glavas (Kieffer Lab) | Navarro et al (Mauvais-Jarvis’s group) | Cell Metabolism | Extranuclear Actions of the Androgen Receptor Enhance Glucose-Stimulated Insulin Secretion in the Male |
May 12, 2016 | Michelle Kwon (Kieffer Lab) | Dai C et al (A Power’s group) | JCI | Stress-impaired transcription factor expression and insulin secretion in transplanted human islets |
May 5, 2016 | Adam Ramzy (Kieffer Lab) | Arda HE et al (S Kim’s group) | Cell Metabolism | Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function |
April 2016 |
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Apr 28, 2016 | Dr. Gareth Lim (Johnson Lab) | Yoshihara E et al (R. Evans’s group) | Cell Metab | ERRγ Is Required for the Metabolic Maturation of Therapeutically Functional Glucose-Responsive β Cells |
Apr 21, 2016 | Dr. Sandra Perreria (Kieffer Lab) | Kabra D et al (P. Pfluger’s group) | Nature Communications | Hypothalamic leptin action is mediated by histone deacetylase 5 |
Apr 14, 2016 | Dr. Honey Modi (Johnson Lab) | Dooley J et al (A Liston’s group) | Nature Genetics | Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes |
Apr 7, 2016 | Ursula Neumann (Kieffer Lab) | Liu Y et al (M Wheeler’s group) | Cell Reports | Rapid Elevation in CMPF May Act As a Tipping Point in Diabetes Development |
March 2016 |
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Mar 24, 2016 | Dr. Søs Skovsø (Johnson Lab) | Jang C et al (Z Arany’s group) | Nature Medicine | A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance |
Mar 17, 2016 | Helen Wong (Marzban Lab) | Zhu S et al (P Arvan’s group) | Diabetes | Monitoring C-Peptide Storage and Secretion in Islet beta-Cells In Vitro and In Vivo |
Mar 10, 2016 | Davide Pacitti (Kieffer Lab) | Ariyachet C et al (Q Zhou’s group) | Cell Stem Cell | Reprogrammed Stomach Tissue as a Renewable Source of Functional beta Cells for Blood Glucose Regulation |
Mar 3, 2016 | Connie Leung (Clee Lab) | Michel M et al (RD Cone’s group) | PNAS | Leptin signaling regulates glucose homeostasis, but not adipostasis, in the zebrafish |
February 2016 |
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Feb 25, 2016 | Michael Bround (Johnson Lab) | Svensson K et al (Bruce Speigleman’s group) | Cell Metabolism | A Secreted Slit2 Fragment Regulates Adipose Tissue Thermogenesis and Metabolic Function |
Feb 19, 2016 | Dr. Majid Mojibian (Kieffer Lab) | Abdulreda et al (Per-Olof Berggren’s group) | Cell Metabolism | Liraglutide Compromises Pancreatic b Cell Function in a Humanized Mouse Model |
Feb 04, 2016 | Dr. Evgeniy Panzhinskiy (Johnson Lab) | Tian XY et al (AJ Chawla’s group) | Cell Metabolism | Thermoneutral Housing Accelerates Metabolic Inflammation to Potentiate Atherosclerosis but Not Insulin Resistance |
January 2016 |
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Jan 28, 2016 | Dr. Suheda Erener (Kieffer Lab) | Campbell JE et al (DJ Drucker’s Group) | Nature Medicine | TCF1 links GIPR signaling to the control of beta cell function and survival |
Jan 21, 2016 | Dr. Nina Quiskamp (Kieffer Lab) | Kumar DP et al (AJ Sanyal’s Group) | JBC | Activation of transmembrane bile acid receptor TGR5 modulates pancreatic islet α cells to promote glucose homeostasis |
Jan 14, 2016 | Dr. Melissa Page (Johnson Lab) | Talukdar S et al (SA Kliewer’s Group) | Cell Metabolism | FGF21 Regulates Sweet and Alcohol Preference |
Jan 7, 2016 | Dr. Maria Glavas (Kieffer Lab) | Bapat SP et al (Y Zheng’s Group) | Nature | Depletion of fat-resident Treg cells prevents age-associated insulin resistance |
December 2015 |
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Dec 17, 2015 | Rene G. Pedroza (Piret Lab) | Wang et al (A Moore’s Group) | Transplantation | Monitoring of Allogeneic Islet Grafts in Nonhuman Primates Using MRI |
Dec 10, 2015 | Anna D’souza (Kieffer Lab) | Suárez-Zamorano et al (M Trajkovski’s Group) | Nature Medicine | Microbiota depletion promotes browning of white adipose tissue and reduces obesity |
November 2015 |
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Nov 26, 2015 | Jelena Kolic (University of Alberta) | Kolic J et al (P Macdonald’s Group) | Multiple | Novel roles for PI3 kinases in rodent and human Islet function |
Nov 19, 2015 | Gareth Lim (Johnson Lab) | Wang QA et al (PE Scherer’s Group) | Nature Cell Biology | Distinct regulatory mechanisms governing embryonic versus adult adipocyte maturation |
Nov 12, 2015 | Sos Skovso (Johnson Lab) | Shen W et al (B Lafitte’s Group) | Nature Communications | Inhibition of DYRK1A and GSK3B induces human beta-cell proliferation |
Nov 5, 2015 | Cara Ellis (Kieffer Lab) | Tharp KM et al (A Stahl’s Group) | Diabetes | Matrix assisted transplantation of functional beige adipose tissue |
October 2015 |
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Oct 29, 2015 | Ursula Neumann (Kieffer Lab) | Ma X et al (E Mueller’s Group) | Cell Metabolism | Celastrol Protects against Obesity and Metabolic Dysfunction through Activation of a HSF1-PGC1a Transcriptional Axis |
Oct 22, 2015 | Dr. Davide Pacitti (Kieffer Lab) | Avrahami D et al (K Kaestner’s Group) | Cell Metabolism | Aging-Dependent Demethylation of Regulatory Elements Correlates with Chromatin State and Improved b Cell Function |
Oct 15, 2015 | Dr. Sandra Pereira (Kieffer Lab) | Wenwen Z et al (A Domingos’s Group) | Cell | Sympathetic Neuro-adipose Connections Mediate Leptin-Driven Lipolysis |
Oct 8, 2015 | Dr. Jenny Bruin (Kieffer Lab) | Fan F et al (X Lou’s Group) | JCI | Dynamin 2 regulates biphasic insulin secretion and plasma glucose homeostasis |
Oct 1, 2015 | Helen Wong (Marzban Lab) | Feng ZC et al (R Wang’s Group) | Diabetes | c-Kit receptor signaling regulates islet vasculature, β-cell survival and function in vivo |
September 2015 |
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Sept 24, 2015 | Howard Cen (Johnson Lab) | Boden G et al (S Merali’s Group) | Science Translational Medicine | Excessive caloric intake acutely causes oxidative stress, GLUT4 carbonylation, and insulin resistance in healthy men |
Sept 17, 2015 | Connie Leung (Clee Lab) | Hall KD et al (L Yannai’s Group) | Cell Metabolism | Calorie for Calorie, Dietary Fat Restriction Results in More Body Fat Loss than Carbohydrate Restriction in People with Obesity |
Sept 10, 2015 | Chiara Toselli (Kieffer Lab) | Ussar S et al (RC Kahn’s Group) | Cell Metabolism | Interactions between Gut Microbiota, Host Genetics and Diet Modulate the Predisposition to Obesity and Metabolic Syndrome |
Sept 3, 2015 | Michael Bround (Johnson Lab) | Santulli G et al (AR Marks’ Group) | JCI | Calcium release channel RyR2 regulates insulin release and glucose homeostasis |
August 2015 |
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Aug 27, 2015 | Dr. Majid Mojibian (Kieffer Lab) | Akbarpour M et al (MG Roncarolo’s Group) | Science Translational Medicine | Insulin B chain 9–23 gene transfer to hepatocytes protects from type 1 diabetes by inducing Ag-specific FoxP3+ Tregs |
Aug 20, 2015 | Dr. Evgeniy Panzhinskiy (Johnson Lab) | Yang L et al (GS Hotamisligil’s Group) | Science | S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction |
Aug 13, 2015 | Dr. Maria Glavas (Kieffer Lab) | Xia JY et al (PE Scherer’s Group) | Cell Metabolism | Targeted Induction of Ceramide Degradation Leads to Improved Systemic Metabolism and Reduced Hepatic Steatosis |
Aug 6, 2015 | Dr. Melissa Page (Johnson Lab) | Brandhorst S et al (VD Longo’s Group) | Cell Metabolism | A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan |
July 2015 |
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July 23, 2015 | Dr. Suheda Erener (Kieffer Lab) | Belgardt BF et al (M. Stoffel’s Group) | Nature Medicine | The microRNA-200 family regulates pancreatic beta cell survival in type 2 diabetes |
July 16, 2015 | René Pedroza (Piret Lab) | Chen T et al (Poznansky’s Group) | Am J Transplant | Alginate Encapsulant Incorporating CXCL12 Supports Long-Term Allo- and Xenoislet Transplantation Without Systemic Immune Suppression |
July 9, 2015 | Michelle Kwon (Kieffer Lab) | Ottaway N et al (Perez-Tilve’s Group) | Cell Metabolism | Diet-Induced Obese Mice Retain Endogenous Leptin Action |
July 2, 2015 | Adam Ramzy (Kieffer Lab) | Kondegowda NG et al (Vasavada’s Group) | Cell Metabolism | Osteoprotegerin and Denosumab Stimulate Human Beta Cell Proliferation through Inhibition of the Receptor Activator of NF-kB Ligand Pathway |
June 2015 |
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June 25, 2015 | Anna D’Souza (Kieffer Lab) | Liu J et al (Umut Ozcan’s Group) | Cell | Treatment of Obesity with Celastrol |
June 18, 2015 | Gareth Lim (Johnson Lab) | Wicks SE (Randall Mynatt’s Group) | PNAS | Impaired mitochondrial fat oxidation induces adaptive remodeling of muscle metabolism |
June 11, 2015 | Cara Ellis (Korbutt Lab) | Ellis CE (Greg Korbutt’s Group) | Multiple | Translational Strategies for the Clinical Transplantation of Neonatal Porcine Islets |
June 4, 2015 | Sandra Pereira (Kieffer Lab) | Duca FA (Tony Lam’s Group) | Nature Medicine | Metformin activates a duodenal Ampk-dependent pathway to lower hepatic glucose production in rats |
May 2015 |
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May 14, 2015 | Howard Cen (Johnson Lab) | Rachel J Perry (G Shulman’s Group) | CELL | Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes |
April 2015 |
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April 30, 2015 | Dr. Davide Pacitti (Kieffer Lab) | Nasif S (M Rubinstein’s Group) | PNAS | Islet 1 specifies the identity of hypothalamic melanocortin neurons and is critical for normal food intake and adiposity in adulthood |
April 23, 2015 | Connie Leung (Clee Lab) | Liu X (W Jin’s Group) | Endocrinology | Brown adipose tissue transplantation reverses obesity in Ob/Ob mice |
April 16, 2015 | Derek Dionne (Johnson Lab) | Ortega-Molina A (M Serrano’s Group) | Cell Metabolism | Pharmacological Inhibition of PI3K Reduces Adiposity and Metabolic Syndrome in Obese Mice and Rhesus Monkeys |
April 9, 2015 | Dr. Majid Mojibian (Kieffer Lab) | Ran FA (F Zhang’s Group) | Nature | In vivo genome editing using Staphylococcus aureus Cas9 |
April 2, 2015 | Michael Bround (Johnson Lab) | Xu HJ (CX Zhang’s Group) | Nature | Two insulin receptors determine alternative wing morphs in planthoppers |
March 2015 |
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March 26, 2015 | Dr. Suheda Erener (Kieffer Lab) | Marquard J (E Lammert’s Group) | Nature Medicine | Characterization of pancreatic NMDA receptors as possible drug targets for diabetes treatment |
March 19, 2015 | Dr. Evgeniy Panzhinskiy (Johnson Lab) | Goginashvili A (R Ricci’s Group) | Science | Insulin secretory granules control autophagy in pancreatic β cells |
March 12, 2015 | Dr. Melissa Page (Johnson Lab) | Fang S (R Evan’s Group) | Nature Medicine | Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance” |
March 5, 2015 | Tobias Albrecht (Johnson Lab) | Stolovich-Rain M (Y Dor’s Group) | Developmental Cell | Weaning triggers a maturation step of pancreatic beta cells |
February 2015 |
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February 26, 2015 | Dr. Nina Quiskamp (Kieffer Lab) | Chou DHC (DG Anderson’s Group) | PNAS | Glucose-responsive insulin activity by covalent modification with aliphatic phenylboronic acid conjugates |
February 19, 2015 | Dr. Maria Glaves (Kieffer Lab) | Alfa RW (SK Kim’s Group) | Cell Metabolism | Suppression of insulin production and secretion by a decretin hormone |
February 12, 2015 | Anna D’souza (Kieffer Lab) | Hasnain SZ (M McGuckin’s Group) | Nature Medicine | Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress |
February 5, 2015 | Chiara Toselli (Kieffer Lab) | Steculorum SM (S Bouret’s Group) | Journal of Clinical Investigation | Neonatal ghrelin programs development of hypothalamic feeding circuits |
December 2014 |
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December 18, 2014 | Dr. Sandra Pereira (Kieffer Lab) | Banks AS (BM Spiegelman’s Group) | Nature | An ERK/Cdk5 axis controls the diabetogenic actions of PPAR-γ |
December 11, 2014 | Dr. Gareth Lim (Johnson Lab) | Wang GX (JD Lin’s Group) | Nature Medicine | The brown fat-enriched secreted factor Nrg4 preserves metabolic homeostasis through attenuation of hepatic lipogenesis |
December 4, 2014 | Ursula Neumann (Kieffer Lab) | Ye R (PE Scherer’s Group) | eLife | Adiponectin is essential for lipid homeostasis and survival under insulin deficiency and promotes β-cell regeneration |
November 2014 |
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November 27, 2014 | Nicole Templeman (Johnson Lab) | Shin AC (C Buettner’s Group) | Cell Metabolism | Brain Insulin Lowers Circulating BCAA Levels by Inducing Hepatic BCAA Catabolism |
November 20, 2014 | Dr. Søs Skovsø (Johnson Lab) | Boucher, J. et al. (CR Kahn’s Group) | PNAS | Insulin and insulin-like growth factor 1 receptors are required for normal expression of imprinted genes |
November 13, 2014 | Connie Leung (Clee Lab) | Thaiss, C.A. et al. (E Elinav’s Group) | Cell | Transkingdom Control of Microbiota Diurnal Oscillations Promotes Metabolic Homeostasis |
November 6, 2014 | Michael Bround (Johnson Lab) | Nelson, O.L. et al. (K Corbit’s Group) | Cell Metabolism | Grizzly Bears Exhibit Augmented Insulin Sensitivity while Obese Prior to a Reversible Insulin Resistance during Hibernation |
October 2014 |
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October 30, 2014 | Dr. Majid Mojibian (Kieffer Lab) | Pagliuca, F. et al. (D Melton’s Group) | Cell | Generation of Functional Human Pancreatic Beta Cells In Vitro |
October 23, 2014 | Derek Dionne (Johnson Lab) | Kern M., et al. (N Kloting’s Group) | Diabetes | Liver-Restricted Repin1 Deficiency Improves Whole- Body Insulin Sensitivity, Alters Lipid Metabolism, and Causes Secondary Changes in Adipose Tissue in Mice |
October 16, 2014 | Dr. Suheda Erener (Kieffer Lab) | Suh J., et al. (R Evan’s Group) | Nature | Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer |
October 9, 2014 | Dr. Evgeniy Panzhinskiy (Johnson Lab) | Liu H., et al. (D Accili’s Group) | Cell Metabolism | Metabolic Inflexibility Impairs Insulin Secretion and Results In MODY-like Diabetes in Triple FoxO-Deficient Mice |
October 2, 2014 | Dr. Nina Quiskamp (Kieffer Lab) | Liu H., et al. (H Deng’s Group) | Cell Research | Systematically labeling developmental stage-specific genes for the study of pancreatic β-cell differentiation from human embryonic stem cells |
September 2014 |
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September 25, 2014 | Tobias Albrecht (Johnson Lab) | Suez, J., et al. (E Elinav’s Group) | Nature | Artificial sweeteners induce glucose intolerance by altering the gut microbiota |
September 18, 2014 | Maria Glavas (Kieffer Lab) | Lee, Y., et al. (R Unger’s Group) | PNAS | Hyperglycemia in rodent models of type 2 diabetes requires insulin-resistant alpha cells |
September 11, 2014 | Melissa Page (Johnson Lab) | Milene, V., et al. (C Frederic’s Group) | Diabetes | Insulin Reverses the High-Fat Diet-Induced Increase in Brain Aβ and Improves Memory in an Animal Model of Alzheimer Disease |
September 4, 2014 | Jenny Bruin (Kieffer Lab) | Chera, S., et al. (PL Herrera’s Group) | Nature | Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers |
August 2014 |
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August 28, 2014 | Anna D’souza (Kieffer Lab) | Owen, BM., et al. (DJ Mangelsdorf’s Group) | Cell Metabolism | FGF21 Acts Centrally to Induce Sympathetic Nerve Activity, Energy Expenditure, and Weight Loss |
August 21, 2014 | Rene G. Pedroza (Piret Lab) | Russell, SJ., et al. (ER Damiano’s Group) | New England Journal of Medicine | Outpatient Glycemic Control with a Bionic Pancreas in Type 1 Diabetes |
August 14, 2014 | Arya Mehran (Johnson Lab) | Cawthorn, WP., et al. (OA MacDougald’s Group) | Cell Metabolism | Bone Marrow Adipose Tissue Is an Endocrine Organ that Contributes to Increased Circulating Adiponectin during Caloric Restriction |
August 7, 2014 | Michelle Kwon (Kieffer Lab) | Lo, JC., et al. (BM Spiegelman’s Group) | Cell | Adipsin Is an Adipokine that Improves β Cell Function in Diabetes |
July 2014 |
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July 31, 2014 | Marta Szabat (Johnson Lab) | Zhang, J., et al. (KH Kaestner’s Group) | Genes and Development | The diabetes gene Hhex maintains delta-cell differentiation and islet function |
July 24, 2014 | Yoo Jin Park (Marzban Lab) | Purwana, I., et al. (Q. Wang’s Group) | Diabetes | GABA promotes human β-cell proliferation and modulates glucose homeostasis |
July 17, 2014 | Sandra Pereira (Kieffer Lab) | Luan, B., et al. (M. Montminy’s Group) | Cell Metabolism | Leptin-Mediated Increases in Catecholamine Signaling Reduce Adipose Tissue Inflammation via Activation of Macrophage HDAC4 |
July 10, 2014 | Gareth Lim (Johnson Lab) | Wernstedt Asterholm I., et al. (PE. Scherer’s Group) | Cell Metabolism | Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling |
July 3, 2014 | Ursula Neumann (Kieffer Lab) | Perry, R., et al. (GI. Shulman’s Group) | Nature Medicine | Leptin reverses diabetes by suppression of the hypothalamic-pituitary-adrenal axis |
June 2014 |
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Date | Presenter | Author | Journal | Title |
June 26, 2014 | Blair Gage (Kieffer Lab) | Chen, Y., et al. (BZ. Stanger’s Group) | Cell Reports | De Novo Formation of Insulin-Producing “Neo-β Cell Islets” from Intestinal Crypts |
June 19, 2014 | Nicole Templeman (Johnson Lab) | Henstridge, DC., et al. (MA. Febbraio’s Group) | Diabetes | Activating HSP72 in Rodent Skeletal Muscle Increases Mitochondrial Number and Oxidative Capacity and Decreases Insulin Resistance |
June 12, 2014 | Connie Leung (Clee Lab) | Stratigopoulos, G., et al. (R. Leibel’s Group) | Cell Metabolism | Hypomorphism for RPGRIP1L, a Ciliary Gene Vicinal to the FTO Locus, Causes Increased Adiposity in Mice |
June 5, 2014 | Michael Bround (Johnson Lab) | Bi, J., et al. (X. Huang’s Group) | Cell Metabolism | Seipin Promotes Adipose Tissue Fat Storage through the ER Ca2+-ATPase SERCAs |
May 2014 |
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Date | Presenter | Author | Journal | Title |
May 29, 2014 | Majid Mojibian (Kieffer Lab) | Smith, EP., et al. (DA. D’Alessio’s Group) | Cell Metabolism | The Role of Beta-Cell Glucagon-like Peptide-1 Signaling in Glucose Regulation and Response to Diabetes Drugs |
May 22, 2014 | Derek Dionne (Johnson Lab) | Prentice, KJ., et al. (MB. Wheeler’s Group) | Cell Metabolism | The furan fatty acid metabolite CMPF is elevated in diabetes and induces beta-cell dysfunction |
May 15, 2014 | Melissa Page (Johnson Lab) | Song, WJ., et al. (M. Hussain’s Group) | Cell Metabolism | Glucagon regulates hepatic kisspeptin to impair insulin secretion |
May 8, 2014 | Chiara Toselli (Kieffer Lab) | Lindahl, M., et al. (M. Saarma’s Group) | Cell Reports | MANF Is Indispensable for the Proliferation and Survival of Pancreatic β Cells |
March 2014 |
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Date | Presenter | Author | Journal | Title |
March 27, 2014 | Michelle Kwon (Kieffer Lab) | Smemo, S., et al. (M. Nobrega’s Group) | Nature | Obesity-associated variants within FTO form long-range functional connections with IRX3. |
March 20, 2014 | Heather Denroche (Kieffer Lab) | Rasmussen, B., et al. (T. Lam’s Group) | Cell Metabolism | Jejunal Leptin-PI3K Signaling Lowers Glucose Production. |
March 6, 2014 | René G. Pedroza (Piret Lab) | Wang, P., et al. (A. Moore’s Group) | Diabetes | GLP-1R-targeting magnetic nanoparticles for pancreatic islet imaging. |
February 2014 |
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Date | Presenter | Author | Journal | Title |
Feb 27, 2014 | Carol Yang (Johnson Lab) | Hoshina, A., et al. (S. Matoba’s Group) | PNAS | Inhibition of p53 preserves Parkin-mediated mitophagy and pancreatic β-cell function in diabetes. |
Feb 20, 2014 | Sandra Pereira (Kieffer Lab) | Khalifeh-Soltani, A., et al. (K. Atabai’s Group) | Nature Medicine | Mfge8 promotes obesity by mediating the uptake of dietary fats and serum fatty acids. |
Feb 13, 2014 | Yoo Jin Park (Marzban Lab) | Gao, T., et al. (B. Stanger’s Group) | Cell Metabolism | Pdx1 Maintains β Cell Identity and Function by Repressing an α Cell Program. |
January 2014 |
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Date | Presenter | Author | Journal | Title |
Jan 30, 2014 | Gareth Lim (Johnson Lab) | Wang J., et al. (G. Ning’s Group) | Nature Cell Biology | Ablation of LGR4 promotes energy expenditure by driving white-to-brown fat switch. |
Jan 23, 2014 | Nicole Templeman (Johnson Lab) | Cohen P. et al. (B. Spiegelman’s Group) | Cell | Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch. |
Jan 16, 2014 | Ursula Neumann (Kieffer Lab) | Tang et al. (H. Sul’s Group) | Cell Metabolism | Desnutrin/ATGL Activates PPAR δ to Promote Mitochondrial Function for Insulin Secretion in Islet β Cells |
Jan 9, 2014 | Blair Gage (Kieffer Lab) | Tattikota et al. (M. Poy’s Group) | Cell Metabolism | Argonaute2 Mediates Compensatory Expansion of the Pancreatic β Cell |
Dec 2013 |
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Date | Presenter | Author | Journal | Title |
Dec 19, 2013 | Connie Leung (Clee Lab) | Ridaura, V., et al. (J. Gordon’s Group) | Science | Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice |
Dec 12, 2013 | Majid Mojibian (Kieffer Lab) | Engin, F., et al. (G. Hotamisligil’s Group) | Science Translational Medicine | Restoration of the Unfolded Protein Response in Pancreatic b Cells Protects Mice Against Type 1 Diabetes |
Dec 5, 2013 | Michael Bround (Johnson Lab) | Ozcan, L., et al. (I. Tabas’s Group) | Cell Metabolism | Activation of Calcium/Calmodulin-Dependent Protein Kinase II in Obesity Mediates Suppression of Hepatic Insulin Signaling |
Nov 2013 |
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Date | Presenter | Author | Journal | Title |
Nov 28, 2013 | Derek Dionne | Owusu-Ansah, E., et al. (N. Perrimon’s Group) | Cell | Muscle Mitohormesis Promotes Longevity via Systemic Repression of Insulin Signaling |
Nov 21, 2013 | Chiara Toselli (Kieffer Lab) | Baeyens, L., et al. (H. Heimberg’s Group) | Nature Biotechnology | Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice |
Nov 14, 2013 | Evgeniy Panzhinskiy (Johnson Lab) | Ohno H., et al. (S. Kajimura’s Group) | Nature | EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex |
Nov 7, 2013 | Melissa Page (Johnson Lab) | Dietrich M., et al. (T. Horvath’s Group) | Cell | Mitochondrial Dynamics Controlled by Mitofusins Regulate Agrp Neuronal Activity and Diet-Induced Obesity |
Oct 2013 |
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Oct 31, 2013 | Maria Glavas | Tamaki M., et al. (H. Watada’s Group) | Journal of Clinical Investigation | The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance |
Oct 24, 2013 | Tobias Albrecht | De Leu, et al. (H. Heimberg’s Group) | Diabetologia | Short-term overexpression of VEGF-A in mouse beta cells indirectly stimulates their proliferation and protects against diabetes. |
Oct 17, 2013 | Anna D’souza | Guo S., et al. (R. Stein’s Group) | Journal of Clinical Investigation | Inactivation of specific beta cell transcription factors in type 2 diabetes |
Oct 10, 2013 | Rene Pedroza | Schulz, T., et al. (A.J. Robins’s Group) | PLOS one | A Scalable System for Production of Functional Pancreatic Progenitors from Human Embryonic Stem Cells |
Oct 3, 2013 | Marta Szabat (Johnson Lab) | Sugiyamaa, T., et al. (S.K. Kim’s Group) | PNAS | Reconstituting pancreas development from purified progenitor cells reveals genes essential for islet differentiation |
Sept 2013 |
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Sept 26, 2013 | Yoo Jin Park (Marzban Lab) | Cai, EP., et al. (M. Woo Group) | PNAS | Retinoblastoma tumor suppressor protein in pancreatic progenitors controls α- and β-cell fate. |
Sept 19, 2013 | Michelle Kwon (Kieffer Lab) | Taylor, B.L., et al. (M. Sander Group) | Cell Reports | Nkx6.1 Is Essential for Maintaining the Functional State of Pancreatic Beta Cells |
Sept 12, 2013 | Sandra Pereira (Kieffer Lab) | Kimura, K., et al. (H. Inoue Group) | Diabetes | Histidine Augments the Suppression of Hepatic Glucose Production by Central Insulin Action |
Sept 5, 2013 | Arya Eimen Mehran (Johnson Lab) |
Liu Z., et al. | Journal of Endocrinology | Neonatal overnutrition in the mice exacerbates high fat diet induced metabolic perturbations |
August 2013 |
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Date | Presenter | Author | Journal | Title |
Aug 29, 2013 | Yu Hsuan Carol Yang (Johnson Lab) |
Ninov N., et al. (Stainier’s Group) | Current Biology | Metabolic regulation of cellular plasticity in the pancreas |
Aug 22, 2013 | Gareth Lim (Johnson Lab) |
Holland W., et al. (P. Scherer’s Group) | Cell Metabolism | An FGF21-Adiponectin-Ceramide Axis Controls Energy Expenditure and Insulin Action in Mice |
Aug 15, 2013 | Nicole Templeman (Johnson Lab) |
Chang HC. (L. Guarente’s Group) | Cell | SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging. |
Aug 8, 2013 | Ursula Neumann (Kieffer Lab) |
H. Cao et al. (G. Hotamisligil’s Group) | Cell Metabolism | Adipocyte Lipid Chaperone aP2 Is a Secreted Adipokine Regulating Hepatic Glucose Production |
Aug 1, 2013 | Heather Denroche (Kieffer Lab) |
Saeidi N et al. (N. Stylopoulos’ Group) | Science | Reprogramming of intestinal glucose metabolism and glycemic control in rats after gastric bypass. |
Date | Presenter | Author | Journal | Title |
March 2012 |
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March 22, 2012 | Frank Huynh (Kieffer Lab) |
Berglund, ED et al. (Joel Elmquist’s group) |
Journal of Clinical Investigation | Direct Leptin Action on POMC Neurons Regulates Glucose Homeostasis and Hepatic Insulin Sensitivity in Mice |
March 15th, 2012 | Eric Xu
(Lynn lab) |
Zhu, H. et al. (George Daley’s group) | Cell | The Lin28/let-7 Axis Regulates Glucose Metabolism |
March 8th, 2012 | Ursula Neumann
(Kieffer lab) |
Dutchak, PA et al. (Steven Kliewer’s group) | Cell | Fibroblast Growth Factor-21 Regulates PPARγ Activity and the Antidiabetic Actions of Thiazolidinediones |
March 1st, 2012 | Maggie Ho
(Clee Lab) |
Gunawardana, SC (David Piston’s group) | Diabetes | Reversal of Type 1 Diabetes in Mice by Brown Adipose Tissue Transplant |
February 2012 |
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Date | Presenter | Author | Journal | Title |
Feb 23rd, 2012 | Suheda Erener
(Kieffer lab) |
Henao-Mejia et al. (Flavell’s group) | Nature | Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity |
Feb 9th, 2012 | Heather Denroche
(Kieffer lab) |
Bostrom et al. (Spiegelman’s group) | Nature | A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis |
Feb 2, 2012 | Majid Mojibian
(Kieffer lab) |
Abdulreda et al. (Per-Olof Berggren’s group) | PNAS | High-resolution, non-invasive longitudinal live imaging of immune responses |
January 2012 |
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Date | Presenter | Author | Journal | Title |
January 26, 2012 | Blair Gage
(Kieffer lab) |
Ku et al. (McManus’ group) | PLoS Genetics | An siRNA Screen in Pancreatic Beta Cells Reveals a Role for Gpr27 in Insulin Production. |
January 19, 2012 | Sarah White
(Johnson lab) |
Takane et al. (A.F. Stewart’s group) | Diabetes | Regulated and Reversible Induction of Adult Human β-Cell Replication. |
January 12, 2012 | Yoo Jin Park
(Marzban lab) |
Dioum et al. (M.H. Cobb’s group) | PNAS | A small molecule differentiation inducer increases insulin production by pancreatic β cells. |
January 5, 2012 | Su-Jin Kim
(McIntosh lab) |
Bastien-Dionne et al. (Jean Buteau’s group) | Diabetes | Glucagon-Like Peptide 1 Inhibits the Sirtuin Deacetylase SirT1 to Stimulate Pancreatic β-Cell Mass Expansion |
December 2011 |
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Date | Presenter | Author | Journal | Title |
December 15th, 2011 | Dr. Eva Tuduri-Lopez
(Kieffer Lab) |
Thorel et al. (Pedro Herrera’s group) | Diabetes | Normal Glucagon Signaling and β-Cell Function After Near-Total a-Cell Ablation in Adult Mice |
December 8th, 2011 | Jaques Courtade
(Verchere Lab) |
Salamekh et al. (Ayyalusamy Ramamoorthy’s group) | Journal of Molecular Biology | A two-site mechanism for the inhibition of IAPP amyloidogenesis by zinc |
December 8th, 2011 | Michael Bround
(Johnson Lab) |
Cao et al. (Matthew During’s group) | Cell Metabolism | White to Brown Fat Phenotypic Switch Induced by Genetic and Environmental Activation of a Hypothalamic-Adipocyte Axis |
November 2011 |
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Date | Presenter | Author | Journal | Title |
November, 24th 2011 | Tobias Albrecht
(Johnson Lab) |
Akirav et al. (Kevan Herold’s group) | PNAS | Detection of β cell death in diabetes using differentially methylated circulating DNA |
November, 17th 2011 |
Michelle Chan (Johnson Lab) |
Jimenez-Preitner et al. (Bernard Thoren’s group) | Cell Metabolism | Plac8 is an inducer of C/EBPβ required for brown fat differentiation, thermoregulation, and control of body weight. |
November, 10th 2011 |
Clara Westwell-Roper (Verchere Lab) |
Ellingsgaard et al. (Marc Donath’s group) | Nature Medicine | Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells. |
November, 3rd 2011 |
Anna D’souza (Kieffer Lab) |
Naito M. et al. (Kazuwa Nakao`s Group) | Diabetes | Therapeutic Impact of Leptin on Diabetes, Diabetic Complications, and Longevity in Insulin-Deficient Diabetic Mice. |
October 2011 |
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Date | Presenter | Author | Journal | Title |
October 27, 2011 |
Dr. Connie Chu (Johnson Lab) |
Chen H. et al. (Seung K. Kim’s Group) | Nature | PDGF signalling controls age-dependent proliferation in pancreatic beta-cells. |
October 20, 2011 |
Arya Mehran (Johnson Lab) |
Remedi MS. et al. (Colin Nichols` Group) | Diabetes | Acute sulfonylurea therapy at disease onset can cause permanent remission of Katp-induced diabetes. |
October 13, 2011 |
Carol Yang (Johnson Lab) |
Wang Z. et al. (Debbie Thurmond`s Group) | Journal of Biological Chemistry | Inhibition or ablation of p21-activated kinase (PAK1) disrupts glucose homeostatic mechanisms in vivo. |
October 6, 2011 |
Gareth Lim (Johnson Lab) |
Kaushik S. et al. (Rajat Singh`s Group) | Cell Metabolism | Autophagy in hypothalamic AgRP neurons regulates food intake and energy balance. |
Sept 2011 |
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Date | Presenter | Author | Journal | Title |
September 29, 2011 |
Nicole Templeman (Johnson Lab) |
Birkenfeld AL. et al. (Gerald Shulman`s Group) | Cell Metabolism | Deletion of the mammalian INDY homolog mimics aspects of dietary restriction and protects against adiposity and insulin resistance in mice. |
September 22, 2011 |
Dr. Maria Glavas (Kieffer Lab) |
Ohtsubo et al. (Jamey Marth’s group) |
Nature Medicine | Pathway to diabetes through attenuation of pancreatic beta cell glycosylation and glucose transport. |
September 15, 2011 |
Dr. Jenny Bruin (Kieffer Lab) |
Kelly et al. (ViaCyte Inc. – formerly Novocell) |
Nature Biotechnology | Cell-Surface Markers for the Isolation of Pancreatic Cell Types Derived from Human Embryonic Stem Cells |
September 8, 2011 |
Ursula Neumann (Kieffer Lab) |
Torres et al. (Masakazu Shiota’s group) |
Diabetes | Defective Glycogenesis Contributes Toward the Inability to Suppress Hepatic Glucose Production in Response to Hyperglycemia and Hyperinsulinemia in Zucker Diabetic Fatty Rats |
September 1, 2011 |
Frank Huynh (Kieffer Lab) |
Hirschey et al. (Eric Verdin’s group) |
Molecular Cell | SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome |
Aug 2011 |
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Date | Presenter | Author | Journal | Title |
August 25, 2011 |
Dr. Majid Mojibian (Kieffer Lab) |
Badami et al., (Marika Falcone’s Group) | Journal of Diabetes | Defective Differentiation of Regulatory FoxP3+ T Cells by Small-Intestinal Dendritic Cells in Patients With Type 1 Diabetes |
August 18, 2011 |
Maggie Ho (Clee Lab) |
Holloway et al. (Alison Holloway’s Group) | Journal of Diabetes | Effect of combining rosiglitazone with either metformin or insulin on β-cell mass and function in an animal model of Type 2 diabetes characterized by reduced β-cell mass at birth |
August 4 , 2011 |
Suheda Erener (Kieffer Lab) |
Salpeter S. et al. (Dor Y. Group) | Endocrinology | Glucose Regulates Cyclin D2 Expression in Quiescent and Replicating Pancreatic {beta}-Cells Through Glycolysis and Calcium Channels. |
June 2011 |
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Date | Presenter | Author | Journal | Title |
June 30, 2011 |
Eva Tuduri-Lopez (Kieffer Lab) |
Rodriguez-Diaz R et al. (Alejandro Caicedo’s Group) | Nature Medicine | Alpha cells secrete acetylcholine as a non-neuronal paracrine signal priming beta cell function in humans. |
June 23, 2011 |
Michael Bround (Johnson Lab) |
Bai P et al. (Johan Auwerx’s Group) | Cell Metabolism | PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation & PARP-2 Regulates SIRT1 Expression and Whole-Body Energy Expenditure. |
June 9, 2011 |
Jaques Courtade (Verchere Lab) |
Meng F and Raleigh DP (Daniel P. Raleigh’s Group) | Journal of Molecular Biology | Inhibition of Glycosaminoglycan-Mediated Amyloid Formation by Islet Amyloid Polypeptide and proIAPP Processing Intermediates. |
June 2, 2011 |
Tobias Albrecht (Johnson Lab) |
Fu S. et al. (Hotamisligil GS. Group) | Nature | Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity. |
May 2011 |
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Date | Presenter | Author | Journal | Title |
May 26, 2011 |
Michelle Chan (Johnson Lab) |
Jorden S. et al. (Bruning J. Group) | Nature Cell Biology | Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism. |
May 19, 2011 |
Connie Chu (Johnson Lab) |
Wu Y. et al. (Leroith D. Group) | Journal of Clinical Investigation | Growth hormone receptor regulates beta-cell hyperplasia and glucose-stimulated insulin secretion in obese mice. |
May 5, 2011 |
Marta Szabat (Johnson Lab) |
He K. et al. (Gauthier B. Group) | Diabetes | In Vivo conditional Pax4 overexpression in mature islet beta-cells prevents stress-induced hyperglycemia in mice. |
April 2011 |
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April 21, 2011 |
Carol Yang (Johnson Lab) |
Sens, S. and Simmons, R.A. (Rebecca. A. Simmons’ Group) | Diabetes | Maternal antioxidant supplementation prevents adiposity in the offspring of Western diet-fed rats. |
April 14, 2011 |
Dr. Jenny Bruin (Kieffer Lab) |
Smukler et al. (Derek van der Kooy’s Group) | Cell Stem Cell | The adult mouse and human pancreas contain rare multipotent stem cells that express insulin |
April 7, 2011 |
Dr. Gareth Lim (Johnson Lab) |
Kim et al. (Josephine M. Egan’s Group) | Diabetes | Cannabinoids Inhibit Insulin Receptor Signaling in Pancreatic β-Cells |
March 2011 |
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Mar 31, 2011 |
Dr. Majid Mojibian (Kieffer Lab) |
Akirav EM et al. (Kevan C Herold’s Group) |
Diabetes | Glucose and Inflammation Control Islet Vascular Density and beta-Cell function in NOD Mice |
Mar 24, 2011 |
Kate Potter (Verchere Lab) |
Daval M et al. (Peter Butler’s Group) |
Diabetes | Cyclin-Dependent Kinase 5 Promotes Pancreatic B-Cell Survival via Fak-Akt Signaling PAthways |
Mar 17, 2011 |
Katie Lee (Clee Lab) |
Qiao L et al. (Jianhua Shao’s Group) |
AJP-Endo Metab | Energy Intake and Adiponectin Gene Expression |
Mar 10, 2011 |
Christian Langelueddecke (Guest Speaker) |
Frank Thévenod’s Group (University of Witten-Herdecke) |
n/aVisiting Scientist | The Role of AMPK in the Acute Regulation of Insulin Secretion in INS-1E Rat Insulinoma Cells |
Mar 2, 2011 |
Frank Huynh (Kieffer Lab) |
Orellana-Gavaldà JM et al. (Dolors Serra’s Group) |
Hepatology | Molecular therapy for obesity and diabetes based on a long-term increase in hepatic fatty-acid oxidation |
February 2011 |
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Feb 24, 2011 |
Anna D’souza (Guest Speaker) |
Michael Riddell’s Group |
n/a Visiting Scientist |
The combined effects of glucocorticoids and high fat diet on hepatic insulin sensitivity and lipid metabolism |
Feb 17, 2011 | Catherine Merchant(Kieffer Lab) | Flock G et al. (Daniel J. Drucker’s Group) | Endocrinology | GPR119 Regulates Murine Glucose Homeostasis Through Incretin Receptor-Dependent and Independent Mechanisms |
Feb 10, 2011 | Heather Denroche(Kieffer Lab) | Lee Y et al. (Roger Unger’s Group) | Diabetes | Glucagon Receptor Knockout Prevents Insulin-Deficient Type 1 Diabetes in Mice |
January 2011 |
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Jan 27, 2011 | Dr. Eva Tuduri-Lopez(Kieffer Lab) | Marroqui L et al. (Ivan Quesada’s Group) | Diabetologia | Leptin downregulates expression of the gene encoding glucagon in alphaTC1-9 cells and mouse islets |
Jan 20, 2011 | Dr. Sujin Kim(McIntosh Lab) | Choi JH et al.(Bruce M. Spiegelman’s Group) | Nature | Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPAR-gamma by Cdk5 |
Jan 13, 2011 | ClaraWestwell-Roper(Verchere Lab) | Masters SL et al. (Luke AJ O’Neill’s Group) | Nature Immunology | Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1beta in type 2 diabetes |
Jan 6, 2011 | Bryan Tennant(Hoffman Lab) | Zong H et al. (Jeffrey E Pessin’s Group) | Diabetes | Enhanced Energy Expenditure, Glucose Utilization, and Insulin Sensitivity in VAMP8 Null Mice |
December 2010 |
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Dec 16, 2010 | Sarah White(Johnson Lab) | Kaneko K et al. (Takashi Kadowaki’s Group) | Nature Immunology | Class IA Phosphatidylinositol 3-Kinasein Pancreatic beta Cells Controls Insulin Secretion by Multiple Mechanisms |
Dec 9, 2010 | Eric Xu(Lynn Lab) | Furuyama K et al. (Shinji Uemoto’s Group) | Nature Genetics | Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine |
Dec 2, 2010 | Maggie Ho(Clee Lab) | Church C et al. (Roger D Cox’s Group) | Nature Genetics | Overexpression of Fto leads to increased food intake and results in obesity |
November 2010 |
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Nov 25, 2010 | Dr. Maria Glavas(Kieffer Lab) | Ng S-F et al. (Margaret J Morris’s Group) | Nature | Chronic high-fat diet in fathers programs b-cell dysfunction in female rat offspring |
Nov 18, 2010 | Michael Bround(Johnson Lab) | Calcraft PJ et al. (Michael X Zhu’s Group) | Nature | NAADP mobilizes calcium from acidic organelles through two-pore channels |
Nov 4, 2010 | Blair Gage(Kieffer Lab) | Christoffersson G et al. (Mia Phillipson’s Group) | Diabetes | Clinical and Experimental Pancreatic Islet Transplantation to Striated Muscle Establishment of a Vascular System Similar to That in Native Islets |
October 2010 |
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Oct 28, 2010 | Michelle Chan(Johnson Lab) | Nelson JD et al. (Karol Bromsztyk’s Group) | Diabetes | Direct recruitment of insulin receptor and ERK signaling cascade to insulin-inducible gene loci |
Oct 21, 2010 | Akiff Manji(Clee Lab) | Zhang X et al. (Aimin Xu’s Group) |
JBC | Adipose Tissue-specific Inhibition of Hypoxia-inducible Factor 1 Induces Obesity and Glucose Intolerance by Impeding Energy Expenditure in Mice |
Oct 14, 2010 | Jaques Courtade(Verchere Lab) | Saraogi I et al. (Andrew D Hamilton’s Group) | Proteomimetics | Synthetic alpha-Helix Mimetics as Agonists and Antagonists of Islet Amyloid Polypeptide Aggregation |
Oct 7, 2010 | Dr. Connie Chu(Johnson Lab) | Claibom KC et al. (Doris A Stoffer’s Group) | JCI | Pcif1 modulates Pdx1 protein stability and pancreatic beta cell function and survival in mice |
September 2010 |
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Sep 30, 2010 | Dr. Suheda Erener(Guest Speaker) | Michael O Hottiger’s Group (University of Zürich) |
n/aVisiting Scientist | Inflammasome-Activated Caspase 7 Cleaves PARP1 to Enhance Inflammatory Gene Expression |
Sep 23, 2010 | Dr. Maria Glavas(Kieffer Lab) | Tam J et al. (George Kunos’s Group) |
JCI | Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity |
Sep 16, 2010 | Tobias Albrecht(Johnson Lab) | Henis-Korenblit S et al. (Cynthia Kenyon’s Group) |
PNSA | Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity |
Sep 9, 2010 | Dr. Marta Szabat(Johnson Lab) | Salpeter SJ et al. (Yuval Dor’s Group) |
Development | Glucose and aging control the quiescence period that follows pancreatic beta cell replication |
Sep 2, 2010 | Arya Mehran(Johnson Lab) | Lopez M et al. (Antonio Vidal-Puig’s Group) |
Nature Medicine | Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance |
August 2010 |
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Aug 26, 2010 | Carol Yang(Johnson Lab) | Wong WPS et al. (Franck Mauvais-Jarvis’s Group) |
PNAS | Extranuclear estrogen receptor-alpha stimulates NeuroD1 binding to the insulin promoter and favors insulin synthesis |
Aug 17, 2010 | Gary Yang(Kwok & Kieffer Labs) | Idevall-Hagren O et al. (Anders Tengholm’s Group) |
JBC | cAMP Mediators of Pulsatile Insulin Secretion from Glucose-stimulated Single beta-cells |
Aug 12, 2010 | Dr. Gareth Lim(Johnson Lab) | Marcheva B et al. (Joseph Bass’s Group) |
Nature | Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes |
Aug 5, 2010 | Kate Potter(Verchere Lab) | Gupta S et al. (Douglas R Cavener’s Group) |
Diabetes | PERK (EIF2AK3) Regulates Proinsulin Trafficking and Quality Control in the Secretory Pathway |
July 2010 |
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Jul 29, 2010 | Dr. Jenny Bruin(Kieffer Lab) | Matveyenko AV et al. (Peter C Butler’s Group) |
AJP Endo Metab | Inconsistent formation and non function of insulin positive cells from pancreatic endoderm derived from human embryonic stem cells in athymic nude rats |
Jul 22, 2010 | Dr. Scott Widenmaier(McIntosh Lab) | Kolka CM et al. (Richard N Bergman’s Group) |
Diabetes | Diet-induced obesity prevents interstitial dispersion of insulin in skeletal muscle |
Jul 15, 2010 | Frank Huynh(Kieffer Lab) | Davis RC et al. (Miklos Peterfy’s Group) |
Diabetes | Early Hepatic Insulin Resistance Precedes the Onset of Diabetes in Obese C57BLKS-db/db Mice |
Jul 8, 2010 | Dr. Dan Luciani(Johnson Lab) | Colsoul B et al. (Rudi Vennekens’s Group) |
PNAS | Loss of high-frequency glucose-induced Ca2+ oscillations in pancreatic islets correlate with impaired glucose tolerance in Trpm5-/- mice |
June 2010 |
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Jun 17, 2010 | Corinne Hoesli(Piret Lab) | Zhang C et al. (Defu Zeng’s Group) |
Diabetes | Induction of chimerism permits low-dose islet grafts in the liver or pancreas to reverse refractory autoimmune diabetes |
Jun 10, 2010 | Katie Lee(Clee Lab) | Chutkow WA et al. (Richard T Lee’s Group) |
Diabetes | Deletion of the alpha-arrestin protein Txnip in mice promotes adiposity and adipogenesis while preserving insulin sensitivity |
Jun 3, 2010 | Dr. Majid Mojibian(Kieffer Lab) | Yi W et al. (Lisa K Denzin’s Group) |
JCI | Targeted regulation of self-peptide presentation prevents type I diabetes in mice without disrupting general immunocompetence |
May 2010 |
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May 27, 2010 | Heather Denroche(Kieffer Lab) | Gu C et al. (Jacqueline E Lee’s Group) |
Cell Metabolism | Pancreatic beta cells require NeuroD to achieve and maintain functional maturity |
May 20, 2010 | Dr. Sujin Kim(McIntosh Lab) | Renner S et al. (Eckhard Wolf’s Group) |
Diabetes | Glucose intolerance and reduced proliferation of pancreatic beta-cells in transgenic pigs with impaired glucose-dependent insulinotropic polypeptide function |
May 13, 2010 | Dr. Eva Tuduri-Lopez(Kieffer Lab) | Hill JW et al. (Joel K Elmquist’s Group) |
Cell Metabolism | Direct Insulin and Leptin Action on Pro-opiomelanocortin Neurons Is Required for Normal Glucose Homeostasis and Fertility |
May 6, 2010 | Catherine Merchant(Kieffer Lab) | Day JW et al. (Matthias H Tschop’s Group) |
Nature Chem Biol | A new glucagon and GLP-1 co-agonist eliminates obesity in rodents |
April 2010 |
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Apr 22, 2010 | Akiff Manji(Clee Lab) | Wueest S et al. (Daniel Konrad’s Group) |
JCI | Deletion of Fas in adipocytes relievesadipose tissue inflammation and hepatic manifestations of obesity in mice |
Apr 8, 2010 | Blair Gage(Kieffer Lab) | Thorel F et al. (Pedro L Herrera’s Group) |
Nature | Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss |
Apr 1, 2010 | Tobias Albrecht(Johnson Lab) | Fornoni A et al. (Camillo Ricordi’s Group) |
Diabetes | Nephrin is expressed on the surface of insulin vesicles and facilitates glucose-stimulated insulin release |
March 2010 |
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Mar 25, 2010 | Dr. Connie Chu(Johnson Lab) | Nakamura T et al. (Gokhan S Hotamisligil’s Group) |
Cell | Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis |
Mar 18, 2010 | Arya Mehran(Johnson Lab) | Vijay-Kumar M et al. (Andrew T Gewirtz’s Group) |
Science | Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5 |
Mar 11, 2010 | Dr. Maria Glavas(Kieffer Lab) | Rosengren AH et al. (Erik Renström’s Group) |
Science | Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes |
Mar 4, 2010 | Carol Yang(Johnson Lab) | Huising MO et al. (Wylie W Vale’s Lab) | PNAS | CRFR1 is expressed on pancreatic beta cells, promotes beta cell proliferation, and potentiates insulin secretion in a glucose-dependent manner |
February 2010 |
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Feb 11, 2010 | Jasna Levi(Kieffer Lab) | Guan XM et al. (Marc L Reitman’s Group) |
Cell Metabolism | Regulation of Energy Homeostasis by Bombesin Receptor Subtype-3: Selective Receptor Agonists for the Treatment of Obesity |
Feb 4, 2010 | Kate Potter(Verchere Lab) | Lu H et al. (Michael B Wheeler’s Group) |
Diabetes | Molecular and metabolic evidence for mitochondrial defects associated with beta-cell dysfunction in a mouse model of type 2 diabetes |
January 2010 |
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Jan 28, 2010 | Frank Huynh(Kieffer Lab) | Hedbacker K et al. (Jeffrey M Friedman’s Group) |
Cell Metabolism | Antidiabetic Effects of IGFBP2, a Leptin-Regulated Gene |
Jan 21, 2010 | Dr. Lucy Marzban | Sachdeva MM et al. (Doris A Stoffer’s Group) |
PNAS | Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress |