Journal Club

WHO WE ARE

The Diabetes Research Group holds a Journal Club on Thursday mornings at 9:00 AM in the Life Sciences Centre Room 5310. All the trainees that are supervised by members of the Diabetes Research Group rotate to present a recently published paper with high impact in the field of diabetes. The presentation will contain sufficient background information and the discussions are open to all attendees. Please contact Dr. Timothy J. Kieffer if you are interested in participating.

UPCOMING PRESENTATION

9:00 AM in the Life Sciences Centre Room 5310.

Date Presenter Author Journal Title
March 30, 2017 Dr. Maria Glavas (Kieffer Lab) Deng et al. (PE Scherer’s group) Science An adipo-biliary-uridine axis that regulates energy homeostasis

PAST PRESENTATIONS

 

March 2017
March 23, 2017 Rene Pedroza (Piret Lab) Berman et al. (A Pileggi’s group) Diabetes Bioengineering the Endocrine Pancreas: Intraomental Islet Transplantation Within a Biologic Resorbable Scaffold
March 16, 2017 Dr. Suheda Erener (Kieffer Lab) Thomou et al. (CR Kahn’s group) Nature Adipose-derived circulating miRNAs regulate gene expression in other tissues
March 9, 2017 Adam Ramzy (Kieffer Lab) Kracht et al. (BO Roep’s group) Nature Medicine Autoimmunity against a defective ribosomal insulin gene product in type 1 diabetes
March 2, 2017 Howard Cen (Johnson Lab) Cheng et al. (VD Longo’s group) Cell Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes
Februrary 2017
February 23, 2017 Dr. Sandra Pereira (Kieffer Lab) Jubota et al. (T Kadowaki’s group) Nature Communications Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity
February 16, 2017 Dr. Davide Pacitti (Kieffer Lab) Hill et al. (K Guillemin’s group) eLife A conserved bacterial protein induces pancreatic beta cell expansion during zebrafish development
January 2017
January 26, 2017 Dr. Søs Skovsø (Johnson Lab) P Li et al. (JM Olefsky’s group) Cell Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance
January 19, 2017 Dr. Jelena Kovic (Johnson Lab) M Sakaguchi et al. (CR Kahn’s group) Cell Metabolism Adipocyte Dynamics and Reversible Metabolic Syndrome in Mice with an Inducible Adipocyte-Specific Deletion of the Insulin Receptor
January 12, 2017 Dr. Cara Ellis (Kieffer Lab) N Ben-Othman et al. (P Collombat’s group) Cell Long-Term GABA Administration Induces Alpha Cell-Mediated Beta-like Cell Neogenesis
December 2016
December 15, 2016 Connie Leung (Clee Lab) AS Williams et al. (DH Wasserman’s group) Diabetes Integrin-linked Kinase is Necessary for the Development of Diet-induced Hepatic Insulin Resistance
December 8, 2016 Nelly Saber(Kieffer Lab) MF Brereton et al. (FM Ashcroft’s group) Nature Communications Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic beta cells
December 1, 2016 Dr. Majid Mojiban (Kieffer Lab) C Cianciaruso et al. (S Baekkeskov’s group) Diabetes Primary human and rat beta cells release the intracellular autoantigens GAD65, IA-2 and proinsulin in exosomes together with cytokine-induced enhancers of immunity
November 2016
November 24, 2016 Michelle Kwon (Kieffer Lab) EE Mulvihill et al. (D Drucker’s group) Cell Metabolism Cellular Sites and Mechanisms Linking Reduction of Dipeptidyl Peptidase-4 Activity to Control of Incretin Hormone Action and Glucose Homeostasis/a>
November 17, 2016 Dr. Evgeniy Panzhinskiy (Johnson Lab) YJ Wang et al (K Kaestner’s group) Cell Metabolism Single-Cell Mass Cytometry Analysis of the Human Endocrine Pancreas
November 10, 2016 Dr. Suheda Erener (Kieffer Lab) X Wei et al (CF Semenkovichs’s group) Diabetes Fatty acid synthesis configures the plasma membrane for inflammation in diabetes
November 3, 2016 Jason Lee (Johnson Lab) T Thayer et al (S Wongs’s group) Diabetes Peripheral Proinsulin Expression Controls Low-Avidity Proinsulin-Reactive CD8 T Cells in Type 1 Diabetes
October 2016
Oct 27, 2016 Dr. Maria Glavas (Kieffer Lab) B Finan (TD Muller’s group) Cell Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease.
Oct 13, 2016 Rene Pedroza (Piret Lab) L van Gurp (EJP deKoning’s group) Diabetologia Sequential intravital imaging reveals in vivo dynamics of pancreatic tissue transplanted under the kidney capsule in mice
Oct 6, 2016 Anna D’souza (Kieffer Lab) N Morton et al (S Horvat’s group) Nature Medicine Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness
September 2016
Sept 29, 2016 Chiara Toselli (Kieffer Lab) Y Zhu et al (PE Scherer’s group) Cell Metabolism Connexin 43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals
Sept 22, 2016 Adam Ramzy (Kieffer Lab) JY Kim-Muller et al (D Accili’s group) Nature Communications Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic β cells in diabetic mice
Sept 15, 2016 Dr. Sandra Pereira (Kieffer Lab) C Garcia-Caceres et al (MH Tschop’s group) Cell Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability
Sept 8, 2016 Ursula Neumann (Kieffer Lab) A Nagarajan et al (N Wajapeyee’s group) Nature Communications MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels
Sept 1, 2016 Dr. Honey Modi (Johnson Lab) J Lu et al (O Andersson’s group) The EMBO Journal IGFBP1 increases β-cell regeneration by promoting α- to β-cell transdifferentiation
August 2016
August 4, 2016 Dr. Cara Ellis (Kieffer Lab) van Bussel et al (JFA Jansen group) Diabetes Functional Brain Networks Are Altered in Type 2 Diabetes and Prediabetes: Signs for Compensation of Cognitive Decrements? The Maastricht Study
July 2016
July 28, 2016 Nelly Saber (Kieffer Lab) Johnston et al (DJ Hodson group) Cell Metabolism Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose
July 21, 2016 Dr. Davide Pacitti (Kieffer Lab) Dorrell et al (M Grompe group) & Bader et al (H Lickert group) Nature Communications & Nature Human islets contain four distinct subtypes of β cells
Identification of proliferative and mature β-cells in the islets of Langerhans
July 14, 2016 Dr. Suheda Erener (Kieffer Lab) Scarlett et al (MW Schwartz group) Nature Medicine Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents
July 7, 2016 Chiara Toselli (Kieffer Lab) Perry et al (GI Shulman’s group) Nature Acetate mediates a microbiome–brain–β-cell axis to promote metabolic syndrome
June 2016
June 30, 2016 Dr. Evgeniy Panzhinskiy (Johnson Lab) Mitchell et al (R. de Cabo’s group) Cell Metabolism Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice
June 23, 2016 Dr. Majid Mojibian (Kieffer Lab) Li et al (B.M. Evers’s group) Nature An obligatory role for neurotensin in high-fat-diet- induced obesity
June 16, 2016 Dr. Nina Quiskamp (Kieffer Lab) Saxena et al (Fussenegger’s group) Nature Communications A programmable synthetic lineage-control network that differentiates human IPSCs into glucose-sensitive insulin-secreting beta-like cells
June 9, 2016 Jason Lee (Johnson Lab) Kodama et al (L. Yu’s group) Diabetes Expression-Based Genome-Wide Association Study Links Vitamin D-Binding Protein With Autoantigenicity in Type 1 Diabetes
May 2016
May 26, 2016 Rene Pedroza (Piret Lab) Vegas et al (D. Anderson’s group) Nature Medicine Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice
May 19, 2016 Dr. Maria Glavas (Kieffer Lab) Navarro et al (Mauvais-Jarvis’s group) Cell Metabolism Extranuclear Actions of the Androgen Receptor Enhance Glucose-Stimulated Insulin Secretion in the Male
May 12, 2016 Michelle Kwon (Kieffer Lab) Dai C et al (A Power’s group) JCI Stress-impaired transcription factor expression and insulin secretion in transplanted human islets
May 5, 2016 Adam Ramzy (Kieffer Lab) Arda HE et al (S Kim’s group) Cell Metabolism Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function
April 2016
Apr 28, 2016 Dr. Gareth Lim (Johnson Lab) Yoshihara E et al (R. Evans’s group) Cell Metab ERRγ Is Required for the Metabolic Maturation of Therapeutically Functional Glucose-Responsive β Cells
Apr 21, 2016 Dr. Sandra Perreria (Kieffer Lab) Kabra D et al (P. Pfluger’s group) Nature Communications Hypothalamic leptin action is mediated by histone deacetylase 5
Apr 14, 2016 Dr. Honey Modi (Johnson Lab) Dooley J et al (A Liston’s group) Nature Genetics Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes
Apr 7, 2016 Ursula Neumann (Kieffer Lab) Liu Y et al (M Wheeler’s group) Cell Reports Rapid Elevation in CMPF May Act As a Tipping Point in Diabetes Development
March 2016
Mar 24, 2016 Dr. Søs Skovsø (Johnson Lab) Jang C et al (Z Arany’s group) Nature Medicine A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance
Mar 17, 2016 Helen Wong (Marzban Lab) Zhu S et al (P Arvan’s group) Diabetes Monitoring C-Peptide Storage and Secretion in Islet beta-Cells In Vitro and In Vivo
Mar 10, 2016 Davide Pacitti (Kieffer Lab) Ariyachet C et al (Q Zhou’s group) Cell Stem Cell Reprogrammed Stomach Tissue as a Renewable Source of Functional beta Cells for Blood Glucose Regulation
Mar 3, 2016 Connie Leung (Clee Lab) Michel M et al (RD Cone’s group) PNAS Leptin signaling regulates glucose homeostasis, but not adipostasis, in the zebrafish
February 2016
Feb 25, 2016 Michael Bround (Johnson Lab) Svensson K et al (Bruce Speigleman’s group) Cell Metabolism A Secreted Slit2 Fragment Regulates Adipose Tissue Thermogenesis and Metabolic Function
Feb 19, 2016 Dr. Majid Mojibian (Kieffer Lab) Abdulreda et al (Per-Olof Berggren’s group) Cell Metabolism Liraglutide Compromises Pancreatic b Cell Function in a Humanized Mouse Model
Feb 04, 2016 Dr. Evgeniy Panzhinskiy (Johnson Lab) Tian XY et al (AJ Chawla’s group) Cell Metabolism Thermoneutral Housing Accelerates Metabolic Inflammation to Potentiate Atherosclerosis but Not Insulin Resistance
January 2016
Jan 28, 2016 Dr. Suheda Erener (Kieffer Lab) Campbell JE et al (DJ Drucker’s Group) Nature Medicine TCF1 links GIPR signaling to the control of beta cell function and survival
Jan 21, 2016 Dr. Nina Quiskamp (Kieffer Lab) Kumar DP et al (AJ Sanyal’s Group) JBC Activation of transmembrane bile acid receptor TGR5 modulates pancreatic islet α cells to promote glucose homeostasis
Jan 14, 2016 Dr. Melissa Page (Johnson Lab) Talukdar S et al (SA Kliewer’s Group) Cell Metabolism FGF21 Regulates Sweet and Alcohol Preference
Jan 7, 2016 Dr. Maria Glavas (Kieffer Lab) Bapat SP et al (Y Zheng’s Group) Nature Depletion of fat-resident Treg cells prevents age-associated insulin resistance
December 2015
Dec 17, 2015 Rene G. Pedroza (Piret Lab) Wang et al (A Moore’s Group) Transplantation Monitoring of Allogeneic Islet Grafts in Nonhuman Primates Using MRI
Dec 10, 2015 Anna D’souza (Kieffer Lab) Suárez-Zamorano et al (M Trajkovski’s Group) Nature Medicine Microbiota depletion promotes browning of white adipose tissue and reduces obesity
November 2015
Nov 26, 2015 Jelena Kolic (University of Alberta) Kolic J et al (P Macdonald’s Group) Multiple Novel roles for PI3 kinases in rodent and human Islet function
Nov 19, 2015 Gareth Lim (Johnson Lab) Wang QA et al (PE Scherer’s Group) Nature Cell Biology Distinct regulatory mechanisms governing embryonic versus adult adipocyte maturation
Nov 12, 2015 Sos Skovso (Johnson Lab) Shen W et al (B Lafitte’s Group) Nature Communications Inhibition of DYRK1A and GSK3B induces human beta-cell proliferation
Nov 5, 2015 Cara Ellis (Kieffer Lab) Tharp KM et al (A Stahl’s Group) Diabetes Matrix assisted transplantation of functional beige adipose tissue
October 2015
Oct 29, 2015 Ursula Neumann (Kieffer Lab) Ma X et al (E Mueller’s Group) Cell Metabolism Celastrol Protects against Obesity and Metabolic Dysfunction through Activation of a HSF1-PGC1a Transcriptional Axis
Oct 22, 2015 Dr. Davide Pacitti (Kieffer Lab) Avrahami D et al (K Kaestner’s Group) Cell Metabolism Aging-Dependent Demethylation of Regulatory Elements Correlates with Chromatin State and Improved b Cell Function
Oct 15, 2015 Dr. Sandra Pereira (Kieffer Lab) Wenwen Z et al (A Domingos’s Group) Cell Sympathetic Neuro-adipose Connections Mediate Leptin-Driven Lipolysis
Oct 8, 2015 Dr. Jenny Bruin (Kieffer Lab) Fan F et al (X Lou’s Group) JCI Dynamin 2 regulates biphasic insulin secretion and plasma glucose homeostasis
Oct 1, 2015 Helen Wong (Marzban Lab) Feng ZC et al (R Wang’s Group) Diabetes c-Kit receptor signaling regulates islet vasculature, β-cell survival and function in vivo
September 2015
Sept 24, 2015 Howard Cen (Johnson Lab) Boden G et al (S Merali’s Group) Science Translational Medicine Excessive caloric intake acutely causes oxidative stress, GLUT4 carbonylation, and insulin resistance in healthy men
Sept 17, 2015 Connie Leung (Clee Lab) Hall KD et al (L Yannai’s Group) Cell Metabolism Calorie for Calorie, Dietary Fat Restriction Results in More Body Fat Loss than Carbohydrate Restriction in People with Obesity
Sept 10, 2015 Chiara Toselli (Kieffer Lab) Ussar S et al (RC Kahn’s Group) Cell Metabolism Interactions between Gut Microbiota, Host Genetics
and Diet Modulate the Predisposition to Obesity and Metabolic Syndrome
Sept 3, 2015 Michael Bround (Johnson Lab) Santulli G et al (AR Marks’ Group) JCI Calcium release channel RyR2 regulates insulin release and glucose homeostasis
August 2015
Aug 27, 2015 Dr. Majid Mojibian (Kieffer Lab) Akbarpour M et al (MG Roncarolo’s Group) Science Translational Medicine Insulin B chain 9–23 gene transfer to hepatocytes protects from type 1 diabetes by inducing Ag-specific FoxP3+ Tregs
Aug 20, 2015 Dr. Evgeniy Panzhinskiy (Johnson Lab) Yang L et al (GS Hotamisligil’s Group) Science S-Nitrosylation links
obesity-associated inflammation to endoplasmic reticulum dysfunction
Aug 13, 2015 Dr. Maria Glavas (Kieffer Lab) Xia JY et al (PE Scherer’s Group) Cell Metabolism Targeted Induction of Ceramide Degradation Leads to Improved Systemic Metabolism and Reduced Hepatic Steatosis
Aug 6, 2015 Dr. Melissa Page (Johnson Lab) Brandhorst S et al (VD Longo’s Group) Cell Metabolism A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan
July 2015
July 23, 2015 Dr. Suheda Erener (Kieffer Lab) Belgardt BF et al (M. Stoffel’s Group) Nature Medicine The microRNA-200 family regulates pancreatic beta cell survival in type 2 diabetes
July 16, 2015 René Pedroza (Piret Lab) Chen T et al (Poznansky’s Group) Am J Transplant Alginate Encapsulant Incorporating CXCL12 Supports Long-Term Allo- and Xenoislet Transplantation Without Systemic Immune Suppression
July 9, 2015 Michelle Kwon (Kieffer Lab) Ottaway N et al (Perez-Tilve’s Group) Cell Metabolism Diet-Induced Obese Mice Retain Endogenous Leptin Action
July 2, 2015 Adam Ramzy (Kieffer Lab) Kondegowda NG et al (Vasavada’s Group) Cell Metabolism Osteoprotegerin and Denosumab Stimulate Human Beta Cell Proliferation through Inhibition of the Receptor Activator of NF-kB Ligand Pathway
June 2015
June 25, 2015 Anna D’Souza (Kieffer Lab) Liu J et al (Umut Ozcan’s Group) Cell Treatment of Obesity with Celastrol
June 18, 2015 Gareth Lim (Johnson Lab) Wicks SE (Randall Mynatt’s Group) PNAS Impaired mitochondrial fat oxidation induces adaptive remodeling of muscle metabolism
June 11, 2015 Cara Ellis (Korbutt Lab) Ellis CE (Greg Korbutt’s Group) Multiple Translational Strategies for the Clinical Transplantation of Neonatal Porcine Islets
June 4, 2015 Sandra Pereira (Kieffer Lab) Duca FA (Tony Lam’s Group) Nature Medicine Metformin activates a duodenal Ampk-dependent pathway to lower hepatic glucose production in rats
May 2015
May 14, 2015 Howard Cen (Johnson Lab) Rachel J Perry (G Shulman’s Group) CELL Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes
April 2015
April 30, 2015 Dr. Davide Pacitti (Kieffer Lab) Nasif S (M Rubinstein’s Group) PNAS Islet 1 specifies the identity of hypothalamic melanocortin neurons and is critical for normal food intake and adiposity in adulthood
April 23, 2015 Connie Leung (Clee Lab) Liu X (W Jin’s Group) Endocrinology Brown adipose tissue transplantation reverses obesity in Ob/Ob mice
April 16, 2015 Derek Dionne (Johnson Lab) Ortega-Molina A (M Serrano’s Group) Cell Metabolism Pharmacological Inhibition of PI3K Reduces Adiposity and Metabolic Syndrome in Obese Mice and Rhesus Monkeys
April 9, 2015 Dr. Majid Mojibian (Kieffer Lab) Ran FA (F Zhang’s Group) Nature In vivo genome editing using Staphylococcus aureus Cas9
April 2, 2015 Michael Bround (Johnson Lab) Xu HJ (CX Zhang’s Group) Nature Two insulin receptors determine alternative wing morphs in planthoppers
March 2015
March 26, 2015 Dr. Suheda Erener (Kieffer Lab) Marquard J (E Lammert’s Group) Nature Medicine Characterization of pancreatic NMDA receptors as possible drug targets for diabetes treatment
March 19, 2015 Dr. Evgeniy Panzhinskiy (Johnson Lab) Goginashvili A (R Ricci’s Group) Science Insulin secretory granules control autophagy in pancreatic β cells
March 12, 2015 Dr. Melissa Page (Johnson Lab) Fang S (R Evan’s Group) Nature Medicine Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance”
March 5, 2015 Tobias Albrecht (Johnson Lab) Stolovich-Rain M (Y Dor’s Group) Developmental Cell Weaning triggers a maturation step of pancreatic beta cells
February 2015
February 26, 2015 Dr. Nina Quiskamp (Kieffer Lab) Chou DHC (DG Anderson’s Group) PNAS Glucose-responsive insulin activity by covalent modification with aliphatic phenylboronic acid conjugates
February 19, 2015 Dr. Maria Glaves (Kieffer Lab) Alfa RW (SK Kim’s Group) Cell Metabolism Suppression of insulin production and secretion by a decretin hormone
February 12, 2015 Anna D’souza (Kieffer Lab) Hasnain SZ (M McGuckin’s Group) Nature Medicine Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress
February 5, 2015 Chiara Toselli (Kieffer Lab) Steculorum SM (S Bouret’s Group) Journal of Clinical Investigation Neonatal ghrelin programs development of hypothalamic feeding circuits
December 2014
December 18, 2014 Dr. Sandra Pereira (Kieffer Lab) Banks AS (BM Spiegelman’s Group) Nature An ERK/Cdk5 axis controls the diabetogenic actions of PPAR-γ
December 11, 2014 Dr. Gareth Lim (Johnson Lab) Wang GX (JD Lin’s Group) Nature Medicine The brown fat-enriched secreted factor Nrg4 preserves metabolic homeostasis through attenuation of hepatic lipogenesis
December 4, 2014 Ursula Neumann (Kieffer Lab) Ye R (PE Scherer’s Group) eLife Adiponectin is essential for lipid homeostasis and survival under insulin deficiency and promotes β-cell regeneration
November 2014
November 27, 2014 Nicole Templeman (Johnson Lab) Shin AC (C Buettner’s Group) Cell Metabolism Brain Insulin Lowers Circulating BCAA Levels by Inducing Hepatic BCAA Catabolism
November 20, 2014 Dr. Søs Skovsø (Johnson Lab) Boucher, J. et al. (CR Kahn’s Group) PNAS Insulin and insulin-like growth factor 1 receptors are required for normal expression of imprinted genes
November 13, 2014 Connie Leung (Clee Lab) Thaiss, C.A. et al. (E Elinav’s Group) Cell Transkingdom Control of Microbiota Diurnal Oscillations Promotes Metabolic Homeostasis
November 6, 2014 Michael Bround (Johnson Lab) Nelson, O.L. et al. (K Corbit’s Group) Cell Metabolism Grizzly Bears Exhibit Augmented Insulin Sensitivity while Obese Prior to a Reversible Insulin Resistance during Hibernation
October 2014
October 30, 2014 Dr. Majid Mojibian (Kieffer Lab) Pagliuca, F. et al. (D Melton’s Group) Cell Generation of Functional Human Pancreatic Beta Cells In Vitro
October 23, 2014 Derek Dionne (Johnson Lab) Kern M., et al. (N Kloting’s Group) Diabetes Liver-Restricted Repin1 Deficiency Improves Whole- Body Insulin Sensitivity, Alters Lipid Metabolism, and Causes Secondary Changes in Adipose Tissue in Mice
October 16, 2014 Dr. Suheda Erener (Kieffer Lab) Suh J., et al. (R Evan’s Group) Nature Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer
October 9, 2014 Dr. Evgeniy Panzhinskiy (Johnson Lab) Liu H., et al. (D Accili’s Group) Cell Metabolism Metabolic Inflexibility Impairs Insulin Secretion and Results In MODY-like Diabetes in Triple FoxO-Deficient Mice
October 2, 2014 Dr. Nina Quiskamp (Kieffer Lab) Liu H., et al. (H Deng’s Group) Cell Research Systematically labeling developmental stage-specific genes for the study of pancreatic β-cell differentiation from human embryonic stem cells
September 2014
September 25, 2014 Tobias Albrecht (Johnson Lab) Suez, J., et al. (E Elinav’s Group) Nature Artificial sweeteners induce glucose intolerance by altering the gut microbiota
September 18, 2014 Maria Glavas (Kieffer Lab) Lee, Y., et al. (R Unger’s Group) PNAS Hyperglycemia in rodent models of type 2 diabetes requires insulin-resistant alpha cells
September 11, 2014 Melissa Page (Johnson Lab) Milene, V., et al. (C Frederic’s Group) Diabetes Insulin Reverses the High-Fat Diet-Induced Increase in Brain Aβ and Improves Memory in an Animal Model of Alzheimer Disease
September 4, 2014 Jenny Bruin (Kieffer Lab) Chera, S., et al. (PL Herrera’s Group) Nature Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers
August 2014
August 28, 2014 Anna D’souza (Kieffer Lab) Owen, BM., et al. (DJ Mangelsdorf’s Group) Cell Metabolism FGF21 Acts Centrally to Induce Sympathetic Nerve Activity, Energy Expenditure, and Weight Loss
August 21, 2014 Rene G. Pedroza (Piret Lab) Russell, SJ., et al. (ER Damiano’s Group) New England Journal of Medicine Outpatient Glycemic Control with a Bionic Pancreas in Type 1 Diabetes
August 14, 2014 Arya Mehran (Johnson Lab) Cawthorn, WP., et al. (OA MacDougald’s Group) Cell Metabolism Bone Marrow Adipose Tissue Is an Endocrine Organ that Contributes to Increased Circulating Adiponectin during Caloric Restriction
August 7, 2014 Michelle Kwon (Kieffer Lab) Lo, JC., et al. (BM Spiegelman’s Group) Cell Adipsin Is an Adipokine that Improves β Cell Function in Diabetes
July 2014
July 31, 2014 Marta Szabat (Johnson Lab) Zhang, J., et al. (KH Kaestner’s Group) Genes and Development The diabetes gene Hhex maintains delta-cell differentiation and islet function
July 24, 2014 Yoo Jin Park (Marzban Lab) Purwana, I., et al. (Q. Wang’s Group) Diabetes GABA promotes human β-cell proliferation and modulates glucose homeostasis
July 17, 2014 Sandra Pereira (Kieffer Lab) Luan, B., et al. (M. Montminy’s Group) Cell Metabolism Leptin-Mediated Increases in Catecholamine Signaling Reduce Adipose Tissue Inflammation via Activation of Macrophage HDAC4
July 10, 2014 Gareth Lim (Johnson Lab) Wernstedt Asterholm I., et al. (PE. Scherer’s Group) Cell Metabolism Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling
July 3, 2014 Ursula Neumann (Kieffer Lab) Perry, R., et al. (GI. Shulman’s Group) Nature Medicine Leptin reverses diabetes by suppression of the hypothalamic-pituitary-adrenal axis
June 2014
Date Presenter Author Journal Title
June 26, 2014 Blair Gage (Kieffer Lab) Chen, Y., et al. (BZ. Stanger’s Group) Cell Reports De Novo Formation of Insulin-Producing “Neo-β Cell Islets” from Intestinal Crypts
June 19, 2014 Nicole Templeman (Johnson Lab) Henstridge, DC., et al. (MA. Febbraio’s Group) Diabetes Activating HSP72 in Rodent Skeletal Muscle Increases Mitochondrial Number and Oxidative Capacity and Decreases Insulin Resistance
June 12, 2014 Connie Leung (Clee Lab) Stratigopoulos, G., et al. (R. Leibel’s Group) Cell Metabolism Hypomorphism for RPGRIP1L, a Ciliary Gene Vicinal to the FTO Locus, Causes Increased Adiposity in Mice
June 5, 2014 Michael Bround (Johnson Lab) Bi, J., et al. (X. Huang’s Group) Cell Metabolism Seipin Promotes Adipose Tissue Fat Storage through the ER Ca2+-ATPase SERCAs
May 2014
Date Presenter Author Journal Title
May 29, 2014 Majid Mojibian (Kieffer Lab) Smith, EP., et al. (DA. D’Alessio’s Group) Cell Metabolism The Role of Beta-Cell Glucagon-like Peptide-1
Signaling in Glucose Regulation and Response to Diabetes Drugs
May 22, 2014 Derek Dionne (Johnson Lab) Prentice, KJ., et al. (MB. Wheeler’s Group) Cell Metabolism The furan fatty acid metabolite CMPF is elevated in diabetes and induces beta-cell dysfunction
May 15, 2014 Melissa Page (Johnson Lab) Song, WJ., et al. (M. Hussain’s Group) Cell Metabolism Glucagon regulates hepatic kisspeptin to impair insulin secretion
May 8, 2014 Chiara Toselli (Kieffer Lab) Lindahl, M., et al. (M. Saarma’s Group) Cell Reports MANF Is Indispensable for the Proliferation and Survival of Pancreatic β Cells
March 2014
Date Presenter Author Journal Title
March 27, 2014 Michelle Kwon (Kieffer Lab) Smemo, S., et al. (M. Nobrega’s Group) Nature Obesity-associated variants within FTO form long-range functional connections with IRX3.
March 20, 2014 Heather Denroche (Kieffer Lab) Rasmussen, B., et al. (T. Lam’s Group) Cell Metabolism Jejunal Leptin-PI3K Signaling
Lowers Glucose Production.
March 6, 2014 René G. Pedroza (Piret Lab) Wang, P., et al. (A. Moore’s Group) Diabetes GLP-1R-targeting magnetic nanoparticles for pancreatic islet imaging.
February 2014
Date Presenter Author Journal Title
Feb 27, 2014 Carol Yang (Johnson Lab) Hoshina, A., et al. (S. Matoba’s Group) PNAS Inhibition of p53 preserves Parkin-mediated mitophagy and pancreatic β-cell function in diabetes.
Feb 20, 2014 Sandra Pereira (Kieffer Lab) Khalifeh-Soltani, A., et al. (K. Atabai’s Group) Nature Medicine Mfge8 promotes obesity by mediating the uptake of dietary fats and serum fatty acids.
Feb 13, 2014 Yoo Jin Park (Marzban Lab) Gao, T., et al. (B. Stanger’s Group) Cell Metabolism Pdx1 Maintains β Cell Identity and Function by Repressing an α Cell Program.
January 2014
Date Presenter Author Journal Title
Jan 30, 2014 Gareth Lim (Johnson Lab) Wang J., et al. (G. Ning’s Group) Nature Cell Biology Ablation of LGR4 promotes energy expenditure by driving white-to-brown fat switch.
Jan 23, 2014 Nicole Templeman (Johnson Lab) Cohen P. et al. (B. Spiegelman’s Group) Cell Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch.
Jan 16, 2014 Ursula Neumann (Kieffer Lab) Tang et al. (H. Sul’s Group) Cell Metabolism Desnutrin/ATGL Activates PPAR δ to Promote Mitochondrial Function for Insulin Secretion in Islet β Cells
Jan 9, 2014 Blair Gage (Kieffer Lab) Tattikota et al. (M. Poy’s Group) Cell Metabolism Argonaute2 Mediates Compensatory Expansion of the Pancreatic β Cell
Dec 2013
Date Presenter Author Journal Title
Dec 19, 2013 Connie Leung (Clee Lab) Ridaura, V., et al. (J. Gordon’s Group) Science Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice
Dec 12, 2013 Majid Mojibian (Kieffer Lab) Engin, F., et al. (G. Hotamisligil’s Group) Science Translational Medicine Restoration of the Unfolded Protein Response in Pancreatic b Cells Protects Mice Against Type 1 Diabetes
Dec 5, 2013 Michael Bround (Johnson Lab) Ozcan, L., et al. (I. Tabas’s Group) Cell Metabolism Activation of Calcium/Calmodulin-Dependent
Protein Kinase II in Obesity Mediates
Suppression of Hepatic Insulin Signaling
Nov 2013
Date Presenter Author Journal Title
Nov 28, 2013 Derek Dionne Owusu-Ansah, E., et al. (N. Perrimon’s Group) Cell Muscle Mitohormesis Promotes Longevity via Systemic Repression of Insulin Signaling
Nov 21, 2013 Chiara Toselli (Kieffer Lab) Baeyens, L., et al. (H. Heimberg’s Group) Nature Biotechnology
Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice
Nov 14, 2013 Evgeniy Panzhinskiy (Johnson Lab) Ohno H., et al. (S. Kajimura’s Group) Nature
EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex
Nov 7, 2013 Melissa Page (Johnson Lab) Dietrich M., et al. (T. Horvath’s Group) Cell
Mitochondrial Dynamics Controlled by Mitofusins Regulate Agrp Neuronal Activity and Diet-Induced Obesity
Oct 2013
Oct 31, 2013 Maria Glavas Tamaki M., et al. (H. Watada’s Group) Journal of Clinical Investigation
The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance
Oct 24, 2013 Tobias Albrecht De Leu, et al. (H. Heimberg’s Group) Diabetologia
Short-term overexpression of VEGF-A in mouse beta cells indirectly stimulates their proliferation and protects against diabetes.
Oct 17, 2013 Anna D’souza Guo S., et al. (R. Stein’s Group) Journal of Clinical Investigation
Inactivation of specific beta cell transcription factors in type 2 diabetes
Oct 10, 2013 Rene Pedroza Schulz, T., et al. (A.J. Robins’s Group) PLOS one
A Scalable System for Production of Functional Pancreatic Progenitors from Human Embryonic Stem Cells
Oct 3, 2013 Marta Szabat (Johnson Lab) Sugiyamaa, T., et al. (S.K. Kim’s Group) PNAS
Reconstituting pancreas development from purified progenitor cells reveals genes essential for islet differentiation
Sept 2013
Sept 26, 2013 Yoo Jin Park (Marzban Lab) Cai, EP., et al. (M. Woo Group) PNAS
Retinoblastoma tumor suppressor protein in pancreatic progenitors controls α- and β-cell fate.
Sept 19, 2013 Michelle Kwon (Kieffer Lab) Taylor, B.L., et al. (M. Sander Group) Cell Reports
Nkx6.1 Is Essential for Maintaining the Functional State of Pancreatic Beta Cells
Sept 12, 2013 Sandra Pereira (Kieffer Lab) Kimura, K., et al. (H. Inoue Group) Diabetes
Histidine Augments the Suppression of Hepatic Glucose Production by Central Insulin Action
Sept 5, 2013 Arya Eimen Mehran
(Johnson Lab)
Liu Z., et al. Journal of Endocrinology
Neonatal overnutrition in the mice exacerbates high fat diet induced metabolic
perturbations
August 2013
Date Presenter Author Journal Title
Aug 29, 2013 Yu Hsuan Carol Yang
(Johnson Lab)
Ninov N., et al. (Stainier’s Group) Current Biology Metabolic regulation of cellular plasticity in the pancreas
Aug 22, 2013 Gareth Lim
(Johnson Lab)
Holland W., et al. (P. Scherer’s Group) Cell Metabolism An FGF21-Adiponectin-Ceramide Axis Controls Energy Expenditure and Insulin Action in Mice
Aug 15, 2013 Nicole Templeman
(Johnson Lab)
Chang HC. (L. Guarente’s Group) Cell SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging.
Aug 8, 2013 Ursula Neumann
(Kieffer Lab)
H. Cao et al. (G. Hotamisligil’s Group) Cell Metabolism Adipocyte Lipid Chaperone aP2 Is a Secreted Adipokine Regulating Hepatic Glucose Production
Aug 1, 2013 Heather Denroche
(Kieffer Lab)
Saeidi N et al. (N. Stylopoulos’ Group) Science Reprogramming of intestinal glucose metabolism and glycemic control in rats after gastric bypass.
March 2012
March 22, 2012 Frank Huynh
(Kieffer Lab)
Berglund, ED et al.
(Joel Elmquist’s group)
Journal of Clinical Investigation Direct Leptin Action on POMC Neurons Regulates Glucose Homeostasis and Hepatic Insulin Sensitivity in Mice
March 15th, 2012 Eric Xu

(Lynn lab)

Zhu, H. et al. (George Daley’s group) Cell
The Lin28/let-7 Axis Regulates Glucose Metabolism
March 8th, 2012 Ursula Neumann

(Kieffer lab)

Dutchak, PA et al. (Steven Kliewer’s group) Cell
Fibroblast Growth Factor-21 Regulates PPARγ Activity and the Antidiabetic Actions of Thiazolidinediones
March 1st, 2012 Maggie Ho

(Clee Lab)

Gunawardana, SC (David Piston’s group) Diabetes
Reversal of Type 1 Diabetes in Mice by Brown Adipose Tissue Transplant
February 2012
Date Presenter Author Journal Title
Feb 23rd, 2012 Suheda Erener

(Kieffer lab)

Henao-Mejia et al. (Flavell’s group) Nature
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
Feb 9th, 2012 Heather Denroche

(Kieffer lab)

Bostrom et al. (Spiegelman’s group) Nature
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Feb 2, 2012 Majid Mojibian

(Kieffer lab)

Abdulreda et al. (Per-Olof Berggren’s group) PNAS
High-resolution, non-invasive longitudinal live imaging of immune responses
January 2012
Date Presenter Author Journal Title
January 26, 2012 Blair Gage

(Kieffer lab)

Ku et al. (McManus’ group) PLoS Genetics
An siRNA Screen in Pancreatic Beta Cells Reveals a Role for Gpr27 in Insulin Production.
January 19, 2012 Sarah White

(Johnson lab)

Takane et al. (A.F. Stewart’s group) Diabetes
Regulated and Reversible Induction of Adult Human β-Cell Replication.
January 12, 2012 Yoo Jin Park

(Marzban lab)

Dioum et al. (M.H. Cobb’s group) PNAS
A small molecule differentiation inducer increases insulin production by pancreatic β cells.
January 5, 2012 Su-Jin Kim

(McIntosh lab)

Bastien-Dionne et al. (Jean Buteau’s group) Diabetes
Glucagon-Like Peptide 1 Inhibits the Sirtuin Deacetylase SirT1 to Stimulate Pancreatic β-Cell Mass Expansion
December 2011
Date Presenter Author Journal Title
December 15th, 2011 Dr. Eva Tuduri-Lopez

(Kieffer Lab)

Thorel et al. (Pedro Herrera’s group) Diabetes
Normal Glucagon Signaling and β-Cell Function After Near-Total a-Cell Ablation in Adult Mice
December 8th, 2011 Jaques Courtade

(Verchere Lab)

Salamekh et al. (Ayyalusamy Ramamoorthy’s group) Journal of Molecular Biology A two-site mechanism for the inhibition of IAPP amyloidogenesis by zinc
December 8th, 2011 Michael Bround

(Johnson Lab)

Cao et al. (Matthew During’s group) Cell Metabolism White to Brown Fat Phenotypic Switch Induced by Genetic and Environmental Activation of a Hypothalamic-Adipocyte Axis
November 2011
Date Presenter Author Journal Title
November, 24th 2011 Tobias Albrecht

(Johnson Lab)

Akirav et al. (Kevan Herold’s group) PNAS Detection of β cell death in diabetes using differentially methylated circulating DNA
November, 17th 2011

Michelle Chan

(Johnson Lab)

Jimenez-Preitner et al. (Bernard Thoren’s group) Cell Metabolism Plac8 is an inducer of C/EBPβ required for brown fat differentiation, thermoregulation, and control of body weight.
November, 10th 2011

Clara Westwell-Roper

(Verchere Lab)

Ellingsgaard et al. (Marc Donath’s group) Nature Medicine Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells.
November, 3rd 2011

Anna D’souza

(Kieffer Lab)

Naito M. et al. (Kazuwa Nakao`s Group) Diabetes Therapeutic Impact of Leptin on Diabetes, Diabetic Complications, and Longevity in Insulin-Deficient Diabetic Mice.
October 2011
Date Presenter Author Journal Title
October 27, 2011

Dr. Connie Chu

(Johnson Lab)

Chen H. et al. (Seung K. Kim’s Group) Nature PDGF signalling controls age-dependent proliferation in pancreatic beta-cells.
October 20, 2011

Arya Mehran

(Johnson Lab)

Remedi MS. et al. (Colin Nichols` Group) Diabetes Acute sulfonylurea therapy at disease onset can cause permanent remission of Katp-induced diabetes.
October 13, 2011

Carol Yang

(Johnson Lab)

Wang Z. et al. (Debbie Thurmond`s Group) Journal of Biological Chemistry Inhibition or ablation of p21-activated kinase (PAK1) disrupts glucose homeostatic mechanisms in vivo.
October 6, 2011

Gareth Lim

(Johnson Lab)

Kaushik S. et al. (Rajat Singh`s Group) Cell Metabolism Autophagy in hypothalamic AgRP neurons regulates food intake and energy balance.
Sept 2011
Date Presenter Author Journal Title
September 29, 2011

Nicole Templeman

(Johnson Lab)

Birkenfeld AL. et al. (Gerald Shulman`s Group) Cell Metabolism Deletion of the mammalian INDY homolog mimics aspects of dietary restriction and protects against adiposity and insulin resistance in mice.
September 22, 2011

Dr. Maria Glavas

(Kieffer Lab)

Ohtsubo et al.
(Jamey Marth’s group)
Nature Medicine Pathway to diabetes through attenuation of pancreatic beta cell glycosylation and glucose transport.
September 15, 2011

Dr. Jenny Bruin

(Kieffer Lab)

Kelly et al.
(ViaCyte Inc. – formerly Novocell)
Nature Biotechnology Cell-Surface Markers for the Isolation of Pancreatic Cell Types Derived from Human Embryonic Stem Cells
September 8, 2011

Ursula Neumann

(Kieffer Lab)

Torres et al.
(Masakazu Shiota’s group)
Diabetes Defective Glycogenesis Contributes Toward the Inability to Suppress Hepatic Glucose Production in Response to Hyperglycemia and Hyperinsulinemia in Zucker Diabetic Fatty Rats
September 1, 2011

Frank Huynh

(Kieffer Lab)

Hirschey et al.
(Eric Verdin’s group)
Molecular Cell SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome
Aug 2011
Date Presenter Author Journal Title
August 25, 2011

Dr. Majid Mojibian

(Kieffer Lab)

Badami et al., (Marika Falcone’s Group) Journal of Diabetes Defective Differentiation of Regulatory FoxP3+ T Cells by Small-Intestinal Dendritic Cells in Patients With Type 1 Diabetes
August 18, 2011

Maggie Ho

(Clee Lab)

Holloway et al. (Alison Holloway’s Group) Journal of Diabetes Effect of combining rosiglitazone with either metformin or insulin on β-cell mass and function in an animal model of Type 2 diabetes characterized by reduced β-cell mass at birth
August 4 , 2011

Suheda Erener

(Kieffer Lab)

Salpeter S. et al. (Dor Y. Group) Endocrinology Glucose Regulates Cyclin D2 Expression in Quiescent and Replicating Pancreatic {beta}-Cells Through Glycolysis and Calcium Channels.
June 2011
Date Presenter Author Journal Title
June 30, 2011

Eva Tuduri-Lopez

(Kieffer Lab)

Rodriguez-Diaz R et al. (Alejandro Caicedo’s Group) Nature Medicine Alpha cells secrete acetylcholine as a non-neuronal paracrine signal priming beta cell function in humans.
June 23, 2011

Michael Bround

(Johnson Lab)

Bai P et al. (Johan Auwerx’s Group) Cell Metabolism PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation
&
PARP-2 Regulates SIRT1 Expression and Whole-Body Energy Expenditure.
June 9, 2011

Jaques Courtade

(Verchere Lab)

Meng F and Raleigh DP (Daniel P. Raleigh’s Group) Journal of Molecular Biology Inhibition of Glycosaminoglycan-Mediated Amyloid Formation by Islet Amyloid Polypeptide and proIAPP Processing Intermediates.
June 2, 2011

Tobias Albrecht

(Johnson Lab)

Fu S. et al. (Hotamisligil GS. Group) Nature Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity.
May 2011
Date Presenter Author Journal Title
May 26, 2011

Michelle Chan

(Johnson Lab)

Jorden S. et al. (Bruning J. Group) Nature Cell Biology Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism.
May 19, 2011

Connie Chu

(Johnson Lab)

Wu Y. et al. (Leroith D. Group) Journal of Clinical Investigation Growth hormone receptor regulates beta-cell hyperplasia and glucose-stimulated insulin secretion in obese mice.
May 5, 2011

Marta Szabat

(Johnson Lab)

He K. et al. (Gauthier B. Group) Diabetes In Vivo conditional Pax4 overexpression in mature islet beta-cells prevents stress-induced hyperglycemia in mice.
April 2011
April 21, 2011

Carol Yang

(Johnson Lab)

Sens, S. and Simmons, R.A. (Rebecca. A. Simmons’ Group) Diabetes Maternal antioxidant supplementation prevents adiposity in the offspring of Western diet-fed rats.
April 14, 2011

Dr. Jenny Bruin

(Kieffer Lab)

Smukler et al. (Derek van der Kooy’s Group) Cell Stem Cell The adult mouse and human pancreas contain rare multipotent stem cells that express insulin
April 7, 2011

Dr. Gareth Lim

(Johnson Lab)

Kim et al. (Josephine M. Egan’s Group) Diabetes Cannabinoids Inhibit Insulin Receptor Signaling in Pancreatic β-Cells
March 2011
Mar 31, 2011

Dr. Majid Mojibian

(Kieffer Lab)

Akirav EM et al.
(Kevan C Herold’s Group)
Diabetes Glucose and Inflammation Control Islet Vascular Density and beta-Cell function in NOD Mice
Mar 24, 2011

Kate Potter

(Verchere Lab)

Daval M et al.
(Peter Butler’s Group)
Diabetes Cyclin-Dependent Kinase 5 Promotes Pancreatic B-Cell Survival via Fak-Akt Signaling PAthways
Mar 17, 2011

Katie Lee

(Clee Lab)

Qiao L et al.
(Jianhua Shao’s Group)
AJP-Endo Metab Energy Intake and Adiponectin Gene Expression
Mar 10, 2011

Christian Langelueddecke

(Guest Speaker)

Frank Thévenod’s Group
(University of Witten-Herdecke)
n/aVisiting Scientist The Role of AMPK in the Acute Regulation of Insulin Secretion in INS-1E Rat Insulinoma Cells
Mar 2, 2011

Frank Huynh

(Kieffer Lab)

Orellana-Gavaldà JM et al.
(Dolors Serra’s Group)
Hepatology Molecular therapy for obesity and diabetes based on a long-term increase in hepatic fatty-acid oxidation
February 2011
Feb 24, 2011

Anna D’souza

(Guest Speaker)

Michael Riddell’s Group
(York University)

n/a

Visiting Scientist

The combined effects of glucocorticoids and high fat diet on hepatic insulin sensitivity and lipid metabolism
Feb 17, 2011 Catherine Merchant(Kieffer Lab) Flock G et al. (Daniel J. Drucker’s Group) Endocrinology GPR119 Regulates Murine Glucose Homeostasis Through Incretin Receptor-Dependent and Independent Mechanisms
Feb 10, 2011 Heather Denroche(Kieffer Lab) Lee Y et al. (Roger Unger’s Group) Diabetes Glucagon Receptor Knockout Prevents Insulin-Deficient Type 1 Diabetes in Mice
January 2011
Jan 27, 2011 Dr. Eva Tuduri-Lopez(Kieffer Lab) Marroqui L et al. (Ivan Quesada’s Group) Diabetologia Leptin downregulates expression of the gene encoding glucagon in alphaTC1-9 cells and mouse islets
Jan 20, 2011 Dr. Sujin Kim(McIntosh Lab) Choi JH et al.(Bruce M. Spiegelman’s Group) Nature Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPAR-gamma by Cdk5
Jan 13, 2011 ClaraWestwell-Roper(Verchere Lab) Masters SL et al. (Luke AJ O’Neill’s Group) Nature Immunology Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1beta in type 2 diabetes
Jan 6, 2011 Bryan Tennant(Hoffman Lab) Zong H et al. (Jeffrey E Pessin’s Group) Diabetes Enhanced Energy Expenditure, Glucose Utilization, and Insulin Sensitivity in VAMP8 Null Mice
December 2010
Dec 16, 2010 Sarah White(Johnson Lab) Kaneko K et al. (Takashi Kadowaki’s Group) Nature Immunology Class IA Phosphatidylinositol 3-Kinasein Pancreatic beta Cells Controls Insulin Secretion by Multiple Mechanisms
Dec 9, 2010 Eric Xu(Lynn Lab) Furuyama K et al. (Shinji Uemoto’s Group) Nature Genetics Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine
Dec 2, 2010 Maggie Ho(Clee Lab) Church C et al. (Roger D Cox’s Group) Nature Genetics Overexpression of Fto leads to increased food intake and results in obesity
November 2010
Nov 25, 2010 Dr. Maria Glavas(Kieffer Lab) Ng S-F et al. (Margaret J Morris’s Group) Nature Chronic high-fat diet in fathers programs b-cell dysfunction in female rat offspring
Nov 18, 2010 Michael Bround(Johnson Lab) Calcraft PJ et al. (Michael X Zhu’s Group) Nature NAADP mobilizes calcium from acidic organelles through two-pore channels
Nov 4, 2010 Blair Gage(Kieffer Lab) Christoffersson G et al. (Mia Phillipson’s Group) Diabetes Clinical and Experimental Pancreatic Islet Transplantation to Striated Muscle Establishment of a Vascular System Similar to That in Native Islets
October 2010
Oct 28, 2010 Michelle Chan(Johnson Lab) Nelson JD et al. (Karol Bromsztyk’s Group) Diabetes Direct recruitment of insulin receptor and ERK signaling cascade to insulin-inducible gene loci
Oct 21, 2010 Akiff Manji(Clee Lab) Zhang X et al.
(Aimin Xu’s Group)
JBC Adipose Tissue-specific Inhibition of Hypoxia-inducible Factor 1 Induces Obesity and Glucose Intolerance by Impeding Energy Expenditure in Mice
Oct 14, 2010 Jaques Courtade(Verchere Lab) Saraogi I et al. (Andrew D Hamilton’s Group) Proteomimetics Synthetic alpha-Helix Mimetics as Agonists and Antagonists of Islet Amyloid Polypeptide Aggregation
Oct 7, 2010 Dr. Connie Chu(Johnson Lab) Claibom KC et al. (Doris A Stoffer’s Group) JCI Pcif1 modulates Pdx1 protein stability and pancreatic beta cell function and survival in mice
September 2010
Sep 30, 2010 Dr. Suheda Erener(Guest Speaker) Michael O Hottiger’s Group
(University of Zürich)
n/aVisiting Scientist Inflammasome-Activated Caspase 7 Cleaves PARP1 to Enhance Inflammatory Gene Expression
Sep 23, 2010 Dr. Maria Glavas(Kieffer Lab) Tam J et al.
(George Kunos’s Group)
JCI Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity
Sep 16, 2010 Tobias Albrecht(Johnson Lab) Henis-Korenblit S et al.
(Cynthia Kenyon’s Group)
PNSA Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity
Sep 9, 2010 Dr. Marta Szabat(Johnson Lab) Salpeter SJ et al.
(Yuval Dor’s Group)
Development Glucose and aging control the quiescence period that follows pancreatic beta cell replication
Sep 2, 2010 Arya Mehran(Johnson Lab) Lopez M et al.
(Antonio Vidal-Puig’s Group)
Nature Medicine Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance
August 2010
Aug 26, 2010 Carol Yang(Johnson Lab) Wong WPS et al.
(Franck Mauvais-Jarvis’s Group)
PNAS Extranuclear estrogen receptor-alpha stimulates NeuroD1 binding to the insulin promoter and favors insulin synthesis
Aug 17, 2010 Gary Yang(Kwok & Kieffer Labs) Idevall-Hagren O et al.
(Anders Tengholm’s Group)
JBC cAMP Mediators of Pulsatile Insulin Secretion from Glucose-stimulated Single beta-cells
Aug 12, 2010 Dr. Gareth Lim(Johnson Lab) Marcheva B et al.
(Joseph Bass’s Group)
Nature Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes
Aug 5, 2010 Kate Potter(Verchere Lab) Gupta S et al.
(Douglas R Cavener’s Group)
Diabetes PERK (EIF2AK3) Regulates Proinsulin Trafficking and Quality Control in the Secretory Pathway
July 2010
Jul 29, 2010 Dr. Jenny Bruin(Kieffer Lab) Matveyenko AV et al.
(Peter C Butler’s Group)
AJP Endo Metab Inconsistent formation and non function of insulin positive cells from pancreatic endoderm derived from human embryonic stem cells in athymic nude rats
Jul 22, 2010 Dr. Scott Widenmaier(McIntosh Lab) Kolka CM et al.
(Richard N Bergman’s Group)
Diabetes Diet-induced obesity prevents interstitial dispersion of insulin in skeletal muscle
Jul 15, 2010 Frank Huynh(Kieffer Lab) Davis RC et al.
(Miklos Peterfy’s Group)
Diabetes Early Hepatic Insulin Resistance Precedes the Onset of Diabetes in Obese C57BLKS-db/db Mice
Jul 8, 2010 Dr. Dan Luciani(Johnson Lab) Colsoul B et al.
(Rudi Vennekens’s Group)
PNAS Loss of high-frequency glucose-induced Ca2+ oscillations in pancreatic islets correlate with impaired glucose tolerance in Trpm5-/- mice
June 2010
Jun 17, 2010 Corinne Hoesli(Piret Lab) Zhang C et al.
(Defu Zeng’s Group)
Diabetes Induction of chimerism permits low-dose islet grafts in the liver or pancreas to reverse refractory autoimmune diabetes
Jun 10, 2010 Katie Lee(Clee Lab) Chutkow WA et al.
(Richard T Lee’s Group)
Diabetes Deletion of the alpha-arrestin protein Txnip in mice promotes adiposity and adipogenesis while preserving insulin sensitivity
Jun 3, 2010 Dr. Majid Mojibian(Kieffer Lab) Yi W et al.
(Lisa K Denzin’s Group)
JCI Targeted regulation of self-peptide presentation prevents type I diabetes in mice without disrupting general immunocompetence
May 2010
May 27, 2010 Heather Denroche(Kieffer Lab) Gu C et al.
(Jacqueline E Lee’s Group)
Cell Metabolism Pancreatic beta cells require NeuroD to achieve and maintain functional maturity
May 20, 2010 Dr. Sujin Kim(McIntosh Lab) Renner S et al.
(Eckhard Wolf’s Group)
Diabetes Glucose intolerance and reduced proliferation of pancreatic beta-cells in transgenic pigs with impaired glucose-dependent insulinotropic polypeptide function
May 13, 2010 Dr. Eva Tuduri-Lopez(Kieffer Lab) Hill JW et al.
(Joel K Elmquist’s Group)
Cell Metabolism Direct Insulin and Leptin Action on Pro-opiomelanocortin Neurons Is Required for Normal Glucose Homeostasis and Fertility
May 6, 2010 Catherine Merchant(Kieffer Lab) Day JW et al.
(Matthias H Tschop’s Group)
Nature Chem Biol A new glucagon and GLP-1 co-agonist eliminates obesity in rodents
April 2010
Apr 22, 2010 Akiff Manji(Clee Lab) Wueest S et al.
(Daniel Konrad’s Group)
JCI Deletion of Fas in adipocytes relievesadipose tissue inflammation and hepatic manifestations of obesity in mice
Apr 8, 2010 Blair Gage(Kieffer Lab) Thorel F et al.
(Pedro L Herrera’s Group)
Nature Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss
Apr 1, 2010 Tobias Albrecht(Johnson Lab) Fornoni A et al.
(Camillo Ricordi’s Group)
Diabetes Nephrin is expressed on the surface of insulin vesicles and facilitates glucose-stimulated insulin release
March 2010
Mar 25, 2010 Dr. Connie Chu(Johnson Lab) Nakamura T et al.
(Gokhan S Hotamisligil’s Group)
Cell Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis
Mar 18, 2010 Arya Mehran(Johnson Lab) Vijay-Kumar M et al.
(Andrew T Gewirtz’s Group)
Science Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5
Mar 11, 2010 Dr. Maria Glavas(Kieffer Lab) Rosengren AH et al.
(Erik Renström’s Group)
Science Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes
Mar 4, 2010 Carol Yang(Johnson Lab) Huising MO et al. (Wylie W Vale’s Lab) PNAS CRFR1 is expressed on pancreatic beta cells, promotes beta cell proliferation, and potentiates insulin secretion in a glucose-dependent manner
February 2010
Feb 11, 2010 Jasna Levi(Kieffer Lab) Guan XM et al.
(Marc L Reitman’s Group)
Cell Metabolism Regulation of Energy Homeostasis by Bombesin Receptor Subtype-3: Selective Receptor Agonists for the Treatment of Obesity
Feb 4, 2010 Kate Potter(Verchere Lab) Lu H et al.
(Michael B Wheeler’s Group)
Diabetes Molecular and metabolic evidence for mitochondrial defects associated with beta-cell dysfunction in a mouse model of type 2 diabetes
January 2010
Jan 28, 2010 Frank Huynh(Kieffer Lab) Hedbacker K et al.
(Jeffrey M Friedman’s Group)
Cell Metabolism Antidiabetic Effects of IGFBP2, a Leptin-Regulated Gene
Jan 21, 2010 Dr. Lucy Marzban Sachdeva MM et al.
(Doris A Stoffer’s Group)
PNAS Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress

 

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