WHO WE ARE
The Diabetes Research Group holds a Journal Club on Thursday mornings at 9:00 AM in the Life Sciences Centre Room 5310. All the trainees that are supervised by members of the Diabetes Research Group rotate to present a recently published paper with high impact in the field of diabetes. The presentation will contain sufficient background information and the discussions are open to all attendees. Please contact Dr. Timothy J. Kieffer if you are interested in participating.
UPCOMING PRESENTATION
9:00 AM in the Life Sciences Centre Room 5310.
| Date | Presenter | Author | Journal | Title |
| March 22, 2012 | Frank Huynh (Kieffer Lab) |
Berglund, ED et al. (Joel Elmquist’s group) |
Journal of Clinical Investigation | Direct Leptin Action on POMC Neurons Regulates Glucose Homeostasis and Hepatic Insulin Sensitivity in Mice |
PAST PRESENTATIONS
March 2012 |
|||||
| Date | Presenter | Author | Journal | Title | |
| March 15th, 2012 | Eric Xu
(Lynn lab) |
Zhu, H. et al. (George Daley’s group) | Cell | The Lin28/let-7 Axis Regulates Glucose Metabolism |
|
| March 8th, 2012 | Ursula Neumann
(Kieffer lab) |
Dutchak, PA et al. (Steven Kliewer’s group) | Cell | Fibroblast Growth Factor-21 Regulates PPARγ Activity and the Antidiabetic Actions of Thiazolidinediones |
|
| March 1st, 2012 | Maggie Ho
(Clee Lab) |
Gunawardana, SC (David Piston’s group) | Diabetes | Reversal of Type 1 Diabetes in Mice by Brown Adipose Tissue Transplant |
|
February 2012 |
|||||
| Date | Presenter | Author | Journal | Title | |
| Feb 23rd, 2012 | Suheda Erener
(Kieffer lab) |
Henao-Mejia et al. (Flavell’s group) | Nature | Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity |
|
| Feb 9th, 2012 | Heather Denroche
(Kieffer lab) |
Bostrom et al. (Spiegelman’s group) | Nature | A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis |
|
| Feb 2, 2012 | Majid Mojibian
(Kieffer lab) |
Abdulreda et al. (Per-Olof Berggren’s group) | PNAS | High-resolution, non-invasive longitudinal live imaging of immune responses |
|
January 2012 |
|||||
| Date | Presenter | Author | Journal | Title | |
| January 26, 2012 | Blair Gage
(Kieffer lab) |
Ku et al. (McManus’ group) | PLoS Genetics | An siRNA Screen in Pancreatic Beta Cells Reveals a Role for Gpr27 in Insulin Production. |
|
| January 19, 2012 | Sarah White
(Johnson lab) |
Takane et al. (A.F. Stewart’s group) | Diabetes | Regulated and Reversible Induction of Adult Human β-Cell Replication. |
|
| January 12, 2012 | Yoo Jin Park
(Marzban lab) |
Dioum et al. (M.H. Cobb’s group) | PNAS | A small molecule differentiation inducer increases insulin production by pancreatic β cells. |
|
| January 5, 2012 | Su-Jin Kim
(McIntosh lab) |
Bastien-Dionne et al. (Jean Buteau’s group) | Diabetes | Glucagon-Like Peptide 1 Inhibits the Sirtuin Deacetylase SirT1 to Stimulate Pancreatic β-Cell Mass Expansion |
|
December 2011 |
|||||
| Date | Presenter | Author | Journal | Title | |
| December 15th, 2011 | Dr. Eva Tuduri-Lopez
(Kieffer Lab) |
Thorel et al. (Pedro Herrera’s group) | Diabetes | Normal Glucagon Signaling and β-Cell Function After Near-Total a-Cell Ablation in Adult Mice |
 |
| December 8th, 2011 | Jaques Courtade
(Verchere Lab) |
Salamekh et al. (Ayyalusamy Ramamoorthy’s group) | Journal of Molecular Biology | A two-site mechanism for the inhibition of IAPP amyloidogenesis by zinc | |
| December 8th, 2011 | Michael Bround
(Johnson Lab) |
Cao et al. (Matthew During’s group) | Cell Metabolism | White to Brown Fat Phenotypic Switch Induced by Genetic and Environmental Activation of a Hypothalamic-Adipocyte Axis | |
November 2011 |
|||||
| Date | Presenter | Author | Journal | Title | |
| November, 24th 2011 | Tobias Albrecht
(Johnson Lab) |
Akirav et al. (Kevan Herold’s group) | PNAS | Detection of β cell death in diabetes using differentially methylated circulating DNA | |
| November, 17th 2011 |
Michelle Chan (Johnson Lab) |
Jimenez-Preitner et al. (Bernard Thoren’s group) | Cell Metabolism | Plac8 is an inducer of C/EBPβ required for brown fat differentiation, thermoregulation, and control of body weight. | |
| November, 10th 2011 |
Clara Westwell-Roper (Verchere Lab) |
Ellingsgaard et al. (Marc Donath’s group) | Nature Medicine | Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells. | |
| November, 3rd 2011 |
Anna D’souza (Kieffer Lab) |
Naito M. et al. (Kazuwa Nakao`s Group) | Diabetes | Therapeutic Impact of Leptin on Diabetes, Diabetic Complications, and Longevity in Insulin-Deficient Diabetic Mice. | |
October 2011 |
|||||
| Date | Presenter | Author | Journal | Title | |
| October 27, 2011 |
Dr. Connie Chu (Johnson Lab) |
Chen H. et al. (Seung K. Kim’s Group) | Nature | PDGF signalling controls age-dependent proliferation in pancreatic beta-cells. | |
| October 20, 2011 |
Arya Mehran (Johnson Lab) |
Remedi MS. et al. (Colin Nichols` Group) | Diabetes | Acute sulfonylurea therapy at disease onset can cause permanent remission of Katp-induced diabetes. | |
| October 13, 2011 |
Carol Yang (Johnson Lab) |
Wang Z. et al. (Debbie Thurmond`s Group) | Journal of Biological Chemistry | Inhibition or ablation of p21-activated kinase (PAK1) disrupts glucose homeostatic mechanisms in vivo. | |
| October 6, 2011 |
Gareth Lim (Johnson Lab) |
Kaushik S. et al. (Rajat Singh`s Group) | Cell Metabolism | Autophagy in hypothalamic AgRP neurons regulates food intake and energy balance. | |
Sept 2011 |
|||||
| Date | Presenter | Author | Journal | Title | |
| September 29, 2011 |
Nicole Templeman (Johnson Lab) |
Birkenfeld AL. et al. (Gerald Shulman`s Group) | Cell Metabolism | Deletion of the mammalian INDY homolog mimics aspects of dietary restriction and protects against adiposity and insulin resistance in mice. | |
| September 22, 2011 |
Dr. Maria Glavas (Kieffer Lab) |
Ohtsubo et al. (Jamey Marth’s group) |
Nature Medicine | Pathway to diabetes through attenuation of pancreatic beta cell glycosylation and glucose transport. | |
| September 15, 2011 |
Dr. Jenny Bruin (Kieffer Lab) |
Kelly et al. (ViaCyte Inc. – formerly Novocell) |
Nature Biotechnology | Cell-Surface Markers for the Isolation of Pancreatic Cell Types Derived from Human Embryonic Stem Cells | |
| September 8, 2011 |
Ursula Neumann (Kieffer Lab) |
Torres et al. (Masakazu Shiota’s group) |
Diabetes | Defective Glycogenesis Contributes Toward the Inability to Suppress Hepatic Glucose Production in Response to Hyperglycemia and Hyperinsulinemia in Zucker Diabetic Fatty Rats | |
| September 1, 2011 |
Frank Huynh (Kieffer Lab) |
Hirschey et al. (Eric Verdin’s group) |
Molecular Cell | SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome | |
Aug 2011 |
|||||
| Date | Presenter | Author | Journal | Title | |
| August 25, 2011 |
Dr. Majid Mojibian (Kieffer Lab) |
Badami et al., (Marika Falcone’s Group) | Journal of Diabetes | Defective Differentiation of Regulatory FoxP3+ T Cells by Small-Intestinal Dendritic Cells in Patients With Type 1 Diabetes | |
| August 18, 2011 |
Maggie Ho (Clee Lab) |
Holloway et al. (Alison Holloway’s Group) | Journal of Diabetes | Effect of combining rosiglitazone with either metformin or insulin on β-cell mass and function in an animal model of Type 2 diabetes characterized by reduced β-cell mass at birth | |
| August 4 , 2011 |
Suheda Erener (Kieffer Lab) |
Salpeter S. et al. (Dor Y. Group) | Endocrinology | Glucose Regulates Cyclin D2 Expression in Quiescent and Replicating Pancreatic {beta}-Cells Through Glycolysis and Calcium Channels. | |
June 2011 |
|||||
| Date | Presenter | Author | Journal | Title | |
| June 30, 2011 |
Eva Tuduri-Lopez (Kieffer Lab) |
Rodriguez-Diaz R et al. (Alejandro Caicedo’s Group) | Nature Medicine | Alpha cells secrete acetylcholine as a non-neuronal paracrine signal priming beta cell function in humans. | |
| June 23, 2011 |
Michael Bround (Johnson Lab) |
Bai P et al. (Johan Auwerx’s Group) | Cell Metabolism | PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation & PARP-2 Regulates SIRT1 Expression and Whole-Body Energy Expenditure. |
PARP-1 PARP-2 |
| June 9, 2011 |
Jaques Courtade (Verchere Lab) |
Meng F and Raleigh DP (Daniel P. Raleigh’s Group) | Journal of Molecular Biology | Inhibition of Glycosaminoglycan-Mediated Amyloid Formation by Islet Amyloid Polypeptide and proIAPP Processing Intermediates. | |
| June 2, 2011 |
Tobias Albrecht (Johnson Lab) |
Fu S. et al. (Hotamisligil GS. Group) | Nature | Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity. | |
May 2011 |
|||||
| Date | Presenter | Author | Journal | Title | |
| May 26, 2011 |
Michelle Chan (Johnson Lab) |
Jorden S. et al. (Bruning J. Group) | Nature Cell Biology | Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism. | |
| May 19, 2011 |
Connie Chu (Johnson Lab) |
Wu Y. et al. (Leroith D. Group) | Journal of Clinical Investigation | Growth hormone receptor regulates beta-cell hyperplasia and glucose-stimulated insulin secretion in obese mice. | |
| May 5, 2011 |
Marta Szabat (Johnson Lab) |
He K. et al. (Gauthier B. Group) | Diabetes | In Vivo conditional Pax4 overexpression in mature islet beta-cells prevents stress-induced hyperglycemia in mice. | |
April 2011 |
|||||
| April 21, 2011 |
Carol Yang (Johnson Lab) |
Sens, S. and Simmons, R.A. (Rebecca. A. Simmons’ Group) | Diabetes | Maternal antioxidant supplementation prevents adiposity in the offspring of Western diet-fed rats. | |
| April 14, 2011 |
Dr. Jenny Bruin (Kieffer Lab) |
Smukler et al. (Derek van der Kooy’s Group) | Cell Stem Cell | The adult mouse and human pancreas contain rare multipotent stem cells that express insulin | |
| April 7, 2011 |
Dr. Gareth Lim (Johnson Lab) |
Kim et al. (Josephine M. Egan’s Group) | Diabetes | Cannabinoids Inhibit Insulin Receptor Signaling in Pancreatic β-Cells | |
March 2011 |
|||||
| Mar 31, 2011 |
Dr. Majid Mojibian (Kieffer Lab) |
Akirav EM et al. (Kevan C Herold’s Group) |
Diabetes | Glucose and Inflammation Control Islet Vascular Density and beta-Cell function in NOD Mice | |
| Mar 24, 2011 |
Kate Potter (Verchere Lab) |
Daval M et al. (Peter Butler’s Group) |
Diabetes | Cyclin-Dependent Kinase 5 Promotes Pancreatic B-Cell Survival via Fak-Akt Signaling PAthways | |
| Mar 17, 2011 |
Katie Lee (Clee Lab) |
Qiao L et al. (Jianhua Shao’s Group) |
AJP-Endo Metab | Energy Intake and Adiponectin Gene Expression | |
| Mar 10, 2011 |
Christian Langelueddecke (Guest Speaker) |
Frank Thévenod’s Group (University of Witten-Herdecke) |
n/aVisiting Scientist | The Role of AMPK in the Acute Regulation of Insulin Secretion in INS-1E Rat Insulinoma Cells | n/a |
| Mar 2, 2011 |
Frank Huynh (Kieffer Lab) |
Orellana-Gavaldà JM et al. (Dolors Serra’s Group) |
Hepatology | Molecular therapy for obesity and diabetes based on a long-term increase in hepatic fatty-acid oxidation | |
February 2011 |
|||||
| Feb 24, 2011 |
Anna D’souza (Guest Speaker) |
Michael Riddell’s Group |
n/a Visiting Scientist |
The combined effects of glucocorticoids and high fat diet on hepatic insulin sensitivity and lipid metabolism | n/a |
| Feb 17, 2011 | Catherine Merchant(Kieffer Lab) | Flock G et al. (Daniel J. Drucker’s Group) | Endocrinology | GPR119 Regulates Murine Glucose Homeostasis Through Incretin Receptor-Dependent and Independent Mechanisms |  |
| Feb 10, 2011 | Heather Denroche(Kieffer Lab) | Lee Y et al. (Roger Unger’s Group) | Diabetes | Glucagon Receptor Knockout Prevents Insulin-Deficient Type 1 Diabetes in Mice | |
January 2011 |
|||||
| Jan 27, 2011 | Dr. Eva Tuduri-Lopez(Kieffer Lab) | Marroqui L et al. (Ivan Quesada’s Group) | Diabetologia | Leptin downregulates expression of the gene encoding glucagon in alphaTC1-9 cells and mouse islets | |
| Jan 20, 2011 | Dr. Sujin Kim(McIntosh Lab) | Choi JH et al.(Bruce M. Spiegelman’s Group) | Nature | Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPAR-gamma by Cdk5 | |
| Jan 13, 2011 | ClaraWestwell-Roper(Verchere Lab) | Masters SL et al. (Luke AJ O’Neill’s Group) | Nature Immunology | Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1beta in type 2 diabetes | |
| Jan 6, 2011 | Bryan Tennant(Hoffman Lab) | Zong H et al. (Jeffrey E Pessin’s Group) | Diabetes | Enhanced Energy Expenditure, Glucose Utilization, and Insulin Sensitivity in VAMP8 Null Mice | |
December 2010 |
|||||
| Dec 16, 2010 | Sarah White(Johnson Lab) | Kaneko K et al. (Takashi Kadowaki’s Group) | Nature Immunology | Class IA Phosphatidylinositol 3-Kinasein Pancreatic beta Cells Controls Insulin Secretion by Multiple Mechanisms | |
| Dec 9, 2010 | Eric Xu(Lynn Lab) | Furuyama K et al. (Shinji Uemoto’s Group) | Nature Genetics | Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine | |
| Dec 2, 2010 | Maggie Ho(Clee Lab) | Church C et al. (Roger D Cox’s Group) | Nature Genetics | Overexpression of Fto leads to increased food intake and results in obesity | |
November 2010 |
|||||
| Nov 25, 2010 | Dr. Maria Glavas(Kieffer Lab) | Ng S-F et al. (Margaret J Morris’s Group) | Nature | Chronic high-fat diet in fathers programs b-cell dysfunction in female rat offspring | |
| Nov 18, 2010 | Michael Bround(Johnson Lab) | Calcraft PJ et al. (Michael X Zhu’s Group) | Nature | NAADP mobilizes calcium from acidic organelles through two-pore channels | |
| Nov 4, 2010 | Blair Gage(Kieffer Lab) | Christoffersson G et al. (Mia Phillipson’s Group) | Diabetes | Clinical and Experimental Pancreatic Islet Transplantation to Striated Muscle Establishment of a Vascular System Similar to That in Native Islets | |
October 2010 |
|||||
| Oct 28, 2010 | Michelle Chan(Johnson Lab) | Nelson JD et al. (Karol Bromsztyk’s Group) | Diabetes | Direct recruitment of insulin receptor and ERK signaling cascade to insulin-inducible gene loci | |
| Oct 21, 2010 | Akiff Manji(Clee Lab) | Zhang X et al. (Aimin Xu’s Group) |
JBC | Adipose Tissue-specific Inhibition of Hypoxia-inducible Factor 1 Induces Obesity and Glucose Intolerance by Impeding Energy Expenditure in Mice | |
| Oct 14, 2010 | Jaques Courtade(Verchere Lab) | Saraogi I et al. (Andrew D Hamilton’s Group) | Proteomimetics | Synthetic alpha-Helix Mimetics as Agonists and Antagonists of Islet Amyloid Polypeptide Aggregation | |
| Oct 7, 2010 | Dr. Connie Chu(Johnson Lab) | Claibom KC et al. (Doris A Stoffer’s Group) | JCI | Pcif1 modulates Pdx1 protein stability and pancreatic beta cell function and survival in mice | |
September 2010 |
|||||
| Sep 30, 2010 | Dr. Suheda Erener(Guest Speaker) | Michael O Hottiger’s Group (University of Zürich) |
n/aVisiting Scientist | Inflammasome-Activated Caspase 7 Cleaves PARP1 to Enhance Inflammatory Gene Expression | n/a |
| Sep 23, 2010 | Dr. Maria Glavas(Kieffer Lab) | Tam J et al. (George Kunos’s Group) |
JCI | Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity | |
| Sep 16, 2010 | Tobias Albrecht(Johnson Lab) | Henis-Korenblit S et al. (Cynthia Kenyon’s Group) |
PNSA | Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity | |
| Sep 9, 2010 | Dr. Marta Szabat(Johnson Lab) | Salpeter SJ et al. (Yuval Dor’s Group) |
Development | Glucose and aging control the quiescence period that follows pancreatic beta cell replication | |
| Sep 2, 2010 | Arya Mehran(Johnson Lab) | Lopez M et al. (Antonio Vidal-Puig’s Group) |
Nature Medicine | Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance | |
August 2010 |
|||||
| Aug 26, 2010 | Carol Yang(Johnson Lab) | Wong WPS et al. (Franck Mauvais-Jarvis’s Group) |
PNAS | Extranuclear estrogen receptor-alpha stimulates NeuroD1 binding to the insulin promoter and favors insulin synthesis | |
| Aug 17, 2010 | Gary Yang(Kwok & Kieffer Labs) | Idevall-Hagren O et al. (Anders Tengholm’s Group) |
JBC | cAMP Mediators of Pulsatile Insulin Secretion from Glucose-stimulated Single beta-cells | |
| Aug 12, 2010 | Dr. Gareth Lim(Johnson Lab) | Marcheva B et al. (Joseph Bass’s Group) |
Nature | Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes | |
| Aug 5, 2010 | Kate Potter(Verchere Lab) | Gupta S et al. (Douglas R Cavener’s Group) |
Diabetes | PERK (EIF2AK3) Regulates Proinsulin Trafficking and Quality Control in the Secretory Pathway | |
July 2010 |
|||||
| Jul 29, 2010 | Dr. Jenny Bruin(Kieffer Lab) | Matveyenko AV et al. (Peter C Butler’s Group) |
AJP Endo Metab | Inconsistent formation and non function of insulin positive cells from pancreatic endoderm derived from human embryonic stem cells in athymic nude rats | |
| Jul 22, 2010 | Dr. Scott Widenmaier(McIntosh Lab) | Kolka CM et al. (Richard N Bergman’s Group) |
Diabetes | Diet-induced obesity prevents interstitial dispersion of insulin in skeletal muscle | |
| Jul 15, 2010 | Frank Huynh(Kieffer Lab) | Davis RC et al. (Miklos Peterfy’s Group) |
Diabetes | Early Hepatic Insulin Resistance Precedes the Onset of Diabetes in Obese C57BLKS-db/db Mice | |
| Jul 8, 2010 | Dr. Dan Luciani(Johnson Lab) | Colsoul B et al. (Rudi Vennekens’s Group) |
PNAS | Loss of high-frequency glucose-induced Ca2+ oscillations in pancreatic islets correlate with impaired glucose tolerance in Trpm5-/- mice | |
June 2010 |
|||||
| Jun 17, 2010 | Corinne Hoesli(Piret Lab) | Zhang C et al. (Defu Zeng’s Group) |
Diabetes | Induction of chimerism permits low-dose islet grafts in the liver or pancreas to reverse refractory autoimmune diabetes | |
| Jun 10, 2010 | Katie Lee(Clee Lab) | Chutkow WA et al. (Richard T Lee’s Group) |
Diabetes | Deletion of the alpha-arrestin protein Txnip in mice promotes adiposity and adipogenesis while preserving insulin sensitivity | |
| Jun 3, 2010 | Dr. Majid Mojibian(Kieffer Lab) | Yi W et al. (Lisa K Denzin’s Group) |
JCI | Targeted regulation of self-peptide presentation prevents type I diabetes in mice without disrupting general immunocompetence | |
May 2010 |
|||||
| May 27, 2010 | Heather Denroche(Kieffer Lab) | Gu C et al. (Jacqueline E Lee’s Group) |
Cell Metabolism | Pancreatic beta cells require NeuroD to achieve and maintain functional maturity | |
| May 20, 2010 | Dr. Sujin Kim(McIntosh Lab) | Renner S et al. (Eckhard Wolf’s Group) |
Diabetes | Glucose intolerance and reduced proliferation of pancreatic beta-cells in transgenic pigs with impaired glucose-dependent insulinotropic polypeptide function | |
| May 13, 2010 | Dr. Eva Tuduri-Lopez(Kieffer Lab) | Hill JW et al. (Joel K Elmquist’s Group) |
Cell Metabolism | Direct Insulin and Leptin Action on Pro-opiomelanocortin Neurons Is Required for Normal Glucose Homeostasis and Fertility | |
| May 6, 2010 | Catherine Merchant(Kieffer Lab) | Day JW et al. (Matthias H Tschop’s Group) |
Nature Chem Biol | A new glucagon and GLP-1 co-agonist eliminates obesity in rodents | |
April 2010 |
|||||
| Apr 22, 2010 | Akiff Manji(Clee Lab) | Wueest S et al. (Daniel Konrad’s Group) |
JCI | Deletion of Fas in adipocytes relievesadipose tissue inflammation and hepatic manifestations of obesity in mice | |
| Apr 8, 2010 | Blair Gage(Kieffer Lab) | Thorel F et al. (Pedro L Herrera’s Group) |
Nature | Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss | |
| Apr 1, 2010 | Tobias Albrecht(Johnson Lab) | Fornoni A et al. (Camillo Ricordi’s Group) |
Diabetes | Nephrin is expressed on the surface of insulin vesicles and facilitates glucose-stimulated insulin release | |
March 2010 |
|||||
| Mar 25, 2010 | Dr. Connie Chu(Johnson Lab) | Nakamura T et al. (Gokhan S Hotamisligil’s Group) |
Cell | Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis | |
| Mar 18, 2010 | Arya Mehran(Johnson Lab) | Vijay-Kumar M et al. (Andrew T Gewirtz’s Group) |
Science | Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5 | |
| Mar 11, 2010 | Dr. Maria Glavas(Kieffer Lab) | Rosengren AH et al. (Erik Renström’s Group) |
Science | Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes | |
| Mar 4, 2010 | Carol Yang(Johnson Lab) | Huising MO et al. (Wylie W Vale’s Lab) | PNAS | CRFR1 is expressed on pancreatic beta cells, promotes beta cell proliferation, and potentiates insulin secretion in a glucose-dependent manner | |
February 2010 |
|||||
| Feb 11, 2010 | Jasna Levi(Kieffer Lab) | Guan XM et al. (Marc L Reitman’s Group) |
Cell Metabolism | Regulation of Energy Homeostasis by Bombesin Receptor Subtype-3: Selective Receptor Agonists for the Treatment of Obesity | |
| Feb 4, 2010 | Kate Potter(Verchere Lab) | Lu H et al. (Michael B Wheeler’s Group) |
Diabetes | Molecular and metabolic evidence for mitochondrial defects associated with beta-cell dysfunction in a mouse model of type 2 diabetes | |
January 2010 |
|||||
| Jan 28, 2010 | Frank Huynh(Kieffer Lab) | Hedbacker K et al. (Jeffrey M Friedman’s Group) |
Cell Metabolism | Antidiabetic Effects of IGFBP2, a Leptin-Regulated Gene | |
| Jan 21, 2010 | Dr. Lucy Marzban | Sachdeva MM et al. (Doris A Stoffer’s Group) |
PNAS | Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress | |
